血糖控制达标的2型糖尿病患者胰岛β细胞分泌功能分级的随访观察

Clinical three-month follow-up observation for classification of β-cell secretary function in glycemic controlled type 2 diabetes patients

目的通过观察胰岛β细胞分泌功能分级在血糖控制达标的2型糖尿病患者中的动态变化,验证该分级标准的科学性。方法收集2011年01月—2012年12月在笔者所在医院就诊、诊断明确、临床资料完整、血糖控制达标、病情稳定的2型糖尿病患者884例,依据胰岛β细胞分泌功能分级标准将患者分别分为3级,即Ⅰ级285例、Ⅱ级296例、Ⅲ级303例,随访3个月后,再次评价其胰岛β细胞分泌功能分级情况,比较其变化并分析影响因素。结果胰岛β细胞分泌功能分级情况在治疗3个月后,总的符合率为91.23%,其中各级的符合率分别为:Ⅰ级94.83%、Ⅱ级86.89%、Ⅲ级91.92%;部分患者(42例,5.3%)胰岛β细胞分泌功能改善的原因可能为体重的降低和胰岛素抵抗的减轻。结论胰岛β细胞分泌功能分级标准可准确评价患者胰岛β细胞分泌功能,可在临床推广应用。

Objective To observe the dynamic changes for classification of 13-cell secretary function in glycemic controlled type 2 diabetes patients and verify the rationality of the classification criteria. Methods From January 2011 to December 2012,846 patients with glycemic controlled type 2 diabetes in author＇s hospital were collected in this study. According to classification criteria of β-cell secretary function,the patients were divided into three groups,respectively,named ClassⅠ , Ⅱ,Ⅲ,for each,282 cases. Following three months,classification of β-cell secretary function was reassessed and analyzed for the relative factor. Results In this study,the classification of β-cell secretary function after three-month therapy were not changed significantly;the coincidence rate was 91.23%,which was respectively in every class： Class Ⅰ 94.83%,Class 11 86.89%,Class m 91.92%. Some patients （42 cases,5.3%） were improved in β-cell secretary function on account of reduction of weight and insulin resistance possibly. Conclusion The classification criteria could accurately assess the β-cell secretary function in glycemic controlled type 2 diabetes patients and has practical application value.