流行性感冒患者病原学与全身炎症反应综合征的相关性分析

Analysis of 531cases of influenza-like illness etiology and its relanvance with SIRS

目的了解流行性感冒患者的病原学分布及病原学与发生全身炎症反应综合征(SIRS)的相关性,为流感病毒导致SIRS提供新的证据。方法对2009年2月-2011年9月医院发热门诊就诊经病毒病原学检测阳性的531例流行性感冒患者,进行流行病学调查,并分析其中符合SIRS诊断标准的患者与病原学的相关性,数据采用SPSS18.0统计软件进行分析。结果在531例流行性感冒患者病毒病原学结果中,季节性甲型流感病毒感染221例占41.62%,新型H1N1甲型流感病毒感染135例占25.42%,乙型流感病毒感染152例占28.63%;3种主要流感病毒感染患者的SIRS发生率分别为12.24%、6.21%、7.91%,组间比较差异无统计学意义。结论流行性感冒患者中以感染季节性甲型流感病毒、甲型H1N1流感病毒和乙型流感病毒为主,并均有>20%的感染者发生了SIRS,仍需更大样本量的观察以阐明流行性感冒患者中SIRS的发病规律及特点。

OBJECTIVE To investigate the viral etiology of influenza in patients with confirmed pathogens and its correlation with systemic inflammatory response syndrome（SIRS）.METHODS From Feb.2009 to Sept.2011,531virus-positive cases with influenza were received in the Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine.This paper investigated the patients for clinical epidemiology and analyzed the relanvance between SIRS patients and etiology.RESULTS Positive diagnoses were achieved：221cases（41.62%）were infected with seasonal influenza A virus,135cases（25.42%）with the new H1N1 influenza A virus,152cases（28.63%）with influenza B virus.In the patients with seasonal influenza A virus,the new H1N1 influenza A virus and influenza B virus,the incidence of SIRS were respectively 29.4%,22.9%and 29.4%.And there was no significance between the groups（P〉0.05）.CONCLUSIONS Most of the influenza patients are mainly infected with seasonal influenza A virus,the new H1N1 influenza A virus and influenza B virus,and more than 20% of them have SIRS.More study is needed to elucidate the occurrence and characteristics of SIRS among influenza patients.