乙型肝炎病毒阳性精神分裂症患者甲状腺激素水平分析

Analysis of thyroid hormone levels in schizophrenia patients with hepatitis B virus infection

目的研究分析精神分裂症伴乙型肝炎病毒(HBV)感染患者甲状腺激素水平,为临床该类患者的诊疗提供理论依据与技术支持。方法随机选取医院2011年4月-2013年4月收住的120例精神分裂患者作为研究对象,其中HBV阳性60例、HBV阴性60例,使用酶联免疫法,测定患者血清甲状腺激素水平,包括游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)以及促甲状腺激素(TSH)水平,数据采用SPSS19.0软件进行统计分析。结果精神分裂HBV阳性患者的甲状腺激素水平与其年龄、性别无关,差异无统计学意义;HBV阳性患者的血清FT3水平为(9.76±1.62)pmol/L,高于HBV阴性患者的(7.04±1.05)pmol/L,差异有统计学意义(P<0.05);HBV阳性患者的血清TSH水平为(3.12±1.28)mU/L,低于HBV阴性患者的(4.67±1.48)mU/L,差异有统计学意义(P<0.05)。结论与HBV阴性患者相比,精神分裂伴HBV阳性患者的FT3水平升高、TSH水平降低,表明肝脏损伤对甲状腺激素的影响显著,大于下丘脑-垂体-甲状腺轴对甲状腺激素的调节作用,该类患者更易形成焦虑、抑郁等精神状况,临床上应密切注意。

OBJECTIVE To analyze thyroid hormone levels in schizophrenia patients with hepatitis B virus（HBV）infection,and summarize the clinical experience to provide a theoretical basis and technical support for the future treatment of such patients.METHODS Totally 120 patients with schizophrenia admitted in the hospital in Apr.2011 to Apr.2013 were randomly selected,of which there were 60HBV-positive patients and 60HBV-negative patients.Enzyme-linked immunoassay was used to detect serum thyroid hormone levels in patients,including free triiodothyronine（FT3）,free thyroxin（FT4）and thyroid stimulating hormone（TSH）levels.Data were analyzed with SPSS 19.0software.RESULTS The thyroid hormone levels in HBV-positive patients with schizophrenia had no correlation with the patient′s age and gender,the difference was not significant.The serum FT3 level in HBVpositive patients was（9.76±1.62）pmol/L,higher than（7.04±1.05）pmol/L in HBV-negative patients,the difference was significant（P〈0.05）.The serum TSH level in the HBV-positive patients was（3.12±1.28）mU/L,lower than（4.67±1.48）mU/L in the HBV-negative patients,the difference was significant（P〈0.05）.CONCLUSIONCompared with the HBV-negative patients with schizophrenia,FT3 was elevated and TSH was decreased in the HBV-positive patients,indicating liver damage had significant impact on thyroid hormone which was greater than the hypothalamus-pituitary-thyroid axis regulation of thyroid hormone,such patients were more likely to develop anxiety,depression and other mental conditions,clinicians should pay close attention to this situation.