女性泌尿生殖道炎患者人乳头状瘤病毒感染研究

Investigation on human papilloma virus infections of women with genitourinary tract inflammation

目的研究女性泌尿生殖道炎症患者人乳头状瘤病毒(HPV)感染状况,为预防HPV感染和宫颈癌的发生提供试验依据。方法选择2012年3月-2013年2月妇科门诊就诊的泌尿生殖道炎症患者365例,采用HPV基因分型技术对其宫颈分泌物进行HPV-DNA分析,数据采用SPSS13.0统计软件进行分析。结果 365例患者中HPV-DNA阳性167例,阳性率为45.7%,共检测到16种HPV高危型和5种低危型;仅一种HPV基因型阳性的患者为122例,其中高危型为99例占81.1%,低危型为23例占18.9%,以HPV16型为最多占29.5%,其次为HPV 58型占19.7%;HPV多重感染为45例,主要以2种高危型多重感染或1种高危型和1种低危型多重感染为主,共32例占71.1%。结论女性泌尿生殖道炎症患者高危型HPV感染率较高,宜常规开展HPV基因检查,预防宫颈癌的发生。

OBJECTIVE To investigate the status of human papilloma virus（HPV）infections in women with genitourinary tract inflammation so as to prevent HPV infection and uterine cervix cancer.METHODS A total of365 women with genitourinary tract inflammation from gynecology clinic were included in the study from Mar.2012 to Feb.2013.HPV genotyping was performed on cervical secretion specimens to analyze HPV-DNA.The data were analyzed by SPSS13.0statistical software.RESULTS Among 365 patients,apositive result of any HPV was found in 167patients（45.7%）and 16 high and 5low risk HPV types were identified.There were 122 patients with any one type HPV infections;in which high risk type HPV infections were 99cases（81.1%）and low risk type HPV infections were 23cases（18.9%）.The most frequent type was HPV 16（29.5%）,followed by type 58（19.7%）.Multiple HPV positive results were found in 45 patients and mainly distributed in 32patients（71.1%）with two high risk types or one high and one low risk type HPV infections.CONCLUSIONS Infection rate of high risk type HPV is high in women with genitourinary tract inflammation in Jingzhou City.So it is suitable to routinely perform HPV genotyping in these patients in order to prevent uterine cervix cancer.