降钙素原与C-反应蛋白联合检测在成人细菌性肺炎中的临床评价

Clinical evaluation of combined detection of serum procalcitonin and C-reactive protein for bacterial pneumonia in adults

目的探讨血清降钙素原(PCT)和C-反应蛋白(CRP)联合检测在成人细菌性肺炎诊断与治疗中的临床评价,以利于疾病的诊断治疗。方法随机选取2013年1-6月进行治疗的细菌性肺炎、病毒性肺炎、支原体肺炎患者各60例,分别对其进行PCT和CRP联合的检测,将60例细菌性肺炎患者按病情轻重程度分组,统计各组PCT和CRP含量,采用SPSS17.0统计软件对数据进行处理。结果肺炎患者PCT水平细菌性肺炎组为(9.31±4.76)μg/L、病毒性肺炎组(1.30±0.68)μg/L、支原体肺炎组(1.45±0.87)μg/L;CRP水平细菌性肺炎组为(64.21±16.97)mmol/L、支原体肺炎组(30.05±10.02)mmol/L、病毒性肺炎组(4.79±1.22)mmol/L,3组比较差异均有统计学意义(P<0.05);细菌性肺炎组患者病情越重,PCT与CRP的水平也越高。结论 PCT及CRP的水平与细菌性肺炎密切相关,两者联合检测对成人细菌性肺炎的诊断和治疗及预后评估均有很好的指导作用。

OBJECTIVE To evaluate clinical effect of combined detection of serum procalcitonin（PCT）and C-reactive protein（CRP）on diagnosis and treatment of bacterial pneumonia in adults in order to facilitate diagnosis and treatment for diseases.METHODS Patients with bacterial pneumonia,viral pneumonia and mycoplasma pneumonia of each 60 cases treated from Jan.2013 to Jun.2013 in our hospital were randomly selected and respectively received combined PCT and CRP detection.The 60 patients with bacterial pneumonia were grouped according to the severity of illness.PCT and CRP contents in patients of each group were summarized and the data were processed by statistical software SPSS17.0.RESULTS PTC of pneumonic patients was（9.31±4.76）μg/L in the bacterial pneumonia group,（1.30±0.68）μg/L in the viral pneumonia group and（1.45±0.87）μg/L in the mycoplasma pneumonia group.CRP was（64.21±16.97）mmol/L in the bacterial pneumonia group,（30.05±10.02）mmol/L in the mycoplasma pneumonia group and（4.79±1.22）mmol/L in the viral pneumonia group.The difference between the three groups was significant（P〈0.05）.The level of PCT and CRP increased along with the severity of bacterial pneumonia.CONCLUSION PCT and CRP levels are closely related with bacterial pneumonia,the combined detection of the two indexes can provide good guidance for diagnosis and treatment as well as prognosis for bacterial pneumonia in adults.