降钙素原对孕妇宫内感染的诊断价值研究

Value of procalcitonin in diagnosis of pregnant women with intrauterine infection

目的探讨降钙素原(PCT)对孕妇宫内感染的诊断价值,为孕妇宫内感染的早期诊断提供依据。方法选择2007年3月-2012年2月孕妇妊娠期宫内细菌感染82例、病毒感染84例、正常孕妇85名,分别为细菌感染组、病毒感染组与对照组,比较3组孕妇血清白细胞(WBC)计数、C-反应蛋白(CRP)、白细胞介素6(IL-6)、中性粒细胞(N)水平及PCT检测结果,数据采用SPSS13.0统计软件进行处理。结果细菌感染组孕妇WBC、CRP、IL-6、N均显著高于对照组与病毒组,病毒感染组显著高于对照组,差异有统计学意义(P<0.05);细菌感染组孕妇PCT阳性率86.6%显著高于病毒感染组的17.9%与对照组的5.9%,差异有统计学意义(P<0.05);PCT对细菌感染诊断敏感度、准确度、特异度、阳性预测值均高于其他检测项目。结论 PCT对孕妇细菌感染检测具有较高的敏感度与特异度,且速度快,准确度高,可作为孕妇宫内感染的早期诊断指标。

OBJECTIVE To discuss the clinical value of procalcitonin in diagnosis of pregnant women with intrauterine infections.METHODS Totally 82 pregnant women with intrauterine bacterial infection were divided into the bacterial group,and 84 with virus infection into the virus group,85 normal pregnant women into the control group,and then the WBC,CRP,IL-6,N were compared among the three groups.Data were processed with SPSS 13.0.RESULTS WBC,CRP,IL-6,N in the bacterial group were significantly higher than the other two groups（P〈0.05）,and those in the virus group were significantly higher compared to the control group（P〈0.05）.Positive rate of PCT in the bacterial group were 86.6%,significantly higher than 17.9%in the virus group and 5.9%in the control group（P〈0.05）.The sensitivity,accuracy,specificity,and positive predictive values of PCT for the diagnosis of bacterial infection were higher than other test items.CONCLUSIONPCT has high sensitivity,specificity,and accuracy in the diagnosis of intrauterine bacterial infections,which is fast and can be used as an early diagnostic marker in the diagnosis of intrauterine bacterial infections in pregnant women.