银黄颗粒配合锡类散治疗小儿疱疹性口炎的临床研究

Clinical observation on Yinhuang decoction and external application of Xilei decoction in treating vesicular stomatitis

目的：观察银黄颗粒口服配合吹敷锡类散治疗小儿疱疹性口炎（vesicular stomatitis，VS）的临床疗效。方法收集2012年1月至2013年10月北京儿童医院口腔科VS患儿126例，按就诊顺序将患儿随机分为两组各63例，对照组口服阿昔洛韦片，治疗组以银黄颗粒口服配合吹敷锡类散治疗。治疗7 d后观察两组患儿的临床疗效及症状改善情况。结果治疗后，治疗组总有效率为95.2%（60/63），对照组为73.0%（46/63），两组总有效率比较，差异有统计学意义（χ2＝17.407，P＜0.05）。治疗后治疗组患儿退热时间、疼痛消失时间、溃疡消退时间、进食恢复正常时间均优于对照组（t值分别为9.590、6.983、5.864、5.814，P＜0.01）。结论锡类散配合银黄颗粒可有效改善小儿VS的临床症状，缩短患儿的发热、疼痛、溃疡消退时间，提高治愈率，疗效优于阿昔洛韦。

Objective To evaluate the effects ofYinhuangdecoction and external application ofXilei decoction in treating vesicular stomatitis.Methods From January 2012 to October 2013, 126 enrolled cases were randomly divided into a treatment group and a control group with 63 in each. The treatment group, which was treated with acycloguanosine tablets as the control group did, was additionally given orallyYinhuang decoction and external application ofXilei decoction. The symptoms, clinical effects comparison were observed before and after the treatment.Results After 7-days treatment, the cure rate of the treatment group was 95.2%（60/63）, and the control group was 73.0%（46/63）. Their difference was conspicuous（χ2=17.407,P〈0.05）. The treatment group attained better curative effects（P〈0.05） and got shorter symptomatic relief time of the duration of fever, time of tain disappeared, time of ulcer dissipated and cure time（The T-value is respectively 9.590, 6.983, 5.864, 5.814,P〈0.01）.ConclusionsYinhuang decoction and external application ofXilei decoction is effective for treating vesicular stomatitis.