益元固肠汤口服联合愈疡液灌肠治疗慢性溃疡性结肠炎疗效分析

The curative effect analysis of oralYiyuan-Guchangdecoctionand enema retention of Yuyangyein treating chronic ulcerative colitis

目的：观察益元固肠汤口服联合愈疡液灌肠对慢性溃疡性结肠炎的临床疗效。方法选择符合纳入标准的UC缓解期患者70例，随机分为两组：对照组34例，给予美沙拉嗪口服，1 g/次，2次/d；治疗组36例，给予益元固肠汤口服，1剂/d，并配合愈疡液每晚保留灌肠。两组均以8周为1个疗程，治疗1疗程后，比较两组临床主要症状、内窥镜、组织病理学、红细胞沉降率（ESR）、C反应蛋白（CRP）及白细胞介素-8（IL-8）、白细胞介素-13（IL-13）的改变情况。结果治疗组总有效率为94.44%（34/36）、对照组为64.71%（22/34），两组比较差异有统计学意义（Z＝-4.207，P＜0.05）。治疗组在临床症状、肠镜黏膜象、黏膜病理组织学疗效优于对照组（P＜0.05）。治疗组ESR、CRP、IL-8、IL-13治疗前分别为（13.5±3.3）mm/h、（8.26±1.54）mg/L、（0.85±0.17）ng/ml、（37.18±14.58）pg/ml，治疗后分别为（7.0±2.4）mm/h、（3.56±1.03）mg/L、（0.38±0.08）ng/ml、（76.33±23.74）pg/ml；对照组ESR、CRP、IL-8、IL-13治疗前分别为（14.5±4.8）mm/h、（8.41±1.36）mg/L、（0.86±0.15）ng/ml、（40.46±14.47）pg/ml，治疗后分别为（7.5±3.5）mm/h、（3.63±1.10）mg/L、（0.36±0.07）ng/ml、（55.84±17.52）pg/ml；两组ESR、CRP、IL-8均较治疗前下降，IL-13治疗后升高（P＜0.05）。治疗后，两组ESR、CRP、IL-8比较，差异无统计学意义（P均＞0.05）；治疗组IL-13高于对照组（P＜0.05）。结论益元固肠汤口服配合愈疡液灌肠治疗脾肾亏虚，瘀毒内蕴证疗效确切。

Objective To research the efficacy of oralYiyuan-Guchangdecoction and enema retention ofYuyangye in treating chronic ulcerative colitis（CUC）.Methods 70 patients of CUC were randomly divided into two groups： a control group of 34 patients, treated by mesalazine（etiasa） orally, 1g/twice daily; and a test group of 36 patients, treated byYuyangyedecoction for oral administration andYuyangyeenema retention. The treatment course of both groups was 8 weeks. The curative effect, clinical symptoms, endoscopic sign and pathology, and ESR, CRP, IL-8, and IL-13 after one course of treatment, were analyzed statistically.Results The total effect of the test group and the control group was 94.44%（34/36） and 64.71%（22/34）, and the difference was significant statistically（Z=-4.207,P〈0.05）. The effects of test group were superior than the control group in terms of the clinical symptoms, endoscopic sign, and histopathology（P〈0.05）. The ESR, CRP, IL-8, IL-13 of the test group were（13.5±3.3）mm/h,（8.26±1.54）mg/L,（0.85±0.17）ng/ml,（37.18± 14.58）pg/ml before the treament, and（7.0±2.4）mm/h, （3.56±1.03）mg/L,（0.38±0.08）ng/ml, （76.33± 23.74）pg/ml after the treatment; The ESR、CRP、IL-8、IL-13 of control group were（14.5±4.8）mm/h, （8.41 ±1.36）mg/L,（0.86±0.15）ng/ml,（40.46±14.47）pg/ml before the treatment and（7.5±3.5）mm/h,（3.63± 1.10）mg/L,（0.36±0.07）ng/ml,（55.84±17.52）pg/ml after the treatment. ESR, CRP and IL-8 of both groups decreased significantly（P〈0.05）, while IL-13 significantly increased（P〈0.05）. ESR, CRP, IL-8 had no obvious statistical significance（P〉0.05）between the two groups, while IL-13 of the test group was superior than the control group（P〈0.05）.Conclusion The therapeutic effect of oralYiyuan-Guchangdecoction and Yuyangyeenema retention is good in treating chronic ulcerative colitis.