“暴露-反应-机制”三联研究模式学术思想及其中医药领域应用

The Academic Theory of Triple Mode Research“Exposure-Response-Mechanism”and Its Application in Chinese Medicine Study

以药效为核心的中药有效物质基础与机制研究是中药现代化研究的重点问题,药代动力学、药理学、分子生物学等不同学科交叉研究的不足使该问题的解决受到一定的限制,中药化学、药理学研究的孤立成果不利于中药及其复方的现代化系统研究进程。本文在前期工作基础上,从学术思想创新及科研方法实践角度,提出了"暴露-反应-机制"三联研究模式,并就其形成的学术背景、科学概念及研究内容等方面进行了论述,可望为中药的效/毒作用物质基础、作用机制研究提供创新性学术思想,为中医药现代化研究提供创新性研究方法。

The active principle and medical mechanism study with the core of pharmacodynamics action is the focal problem to Chinese Medicine modernization,and the deficiency of cross study among chemistry of Chinese Medicine,pharmacology and molecular biology in-fluences its resolution.Based on our former study,from the aspects of academic innovation and scientific research practice,a new Triple Research Mode “Exposure-Response-Mechanism”is proposed.Its academic background,scientific concept and research content are discussed,and we hope to provide a new academic thinking to the study of Chinese medicine pharmacological and /or toxicological mate-rials and mechanisms,so as to supply the innovative methods to modernization of Chinese medicine.