廊坊市流动人口结核病耐药状况分析

Floating population tuberculosis drug resistance analysis in Langfang

目的初步了解河北省廊坊地区流动人口结核病耐药状况,为有效控制耐药结核病流行提供依据。方法采集2009-2013年流动人口中新发现的肺结核病人涂阳痰标本,经培养鉴定为结核分枝杆菌的菌株采用比例法测定对异烟肼、利福平、乙胺丁醇、链霉素、卡那霉素、氧氟沙星6种药物敏感性,并将分离自流动人口的菌株耐药性与常住人口进行比较。结果进行结核分枝杆菌耐药监测共1 764株,耐药菌株819株,总耐药率为46.4%(819/1 764),耐多药率为11.5%(203/1 764),广泛耐药率为1.1%(20/1 764);其中流动人口总耐药率为55.1%(205/372),耐多药率为15.1%(56/372),广泛耐药率为1.9%(7/372);常住人口总耐药率为44.1%(614/1 392),耐多药率为10.6%(147/1 392),广泛耐药率为0.9%(13/1 392)。流动人口组的总耐药率、耐多药率、广泛耐药率均高于常住人口组,差异有统计学意义(χ2值分别为14.3、5.8和2.4,P均<0.05)。结论廊坊市流动人口的结核耐药率显著高于该地区常住人口的结核耐药率,应根据流动人口的特点加强结核病防治措施。

ulation in Objective To preliminarily understand Langfang area of Hebei province, provide lence. Methods Select the sputum of the pulmonary status of drug resistance in tuberculosis from floating popthe basis for effective control of drug - resistant TB prevatuberculosis patients with smear positive for the first time from floating people in Langfang during 2009 - 2013, identify part of them as mycobacterium tuberculosis from all the bacterial strain by bacterial culture, examine separately its drug sensitivity of those positive bacterial strain to antituberculosis drugs as isoniazid, rifampicin, ethambutol, streptomycin, kanamycin and ofloxacin by using proportion method. Make a drug resistance comparison between the bacterial strain from floating population and resident population. Results Mycobacterium tuberculosis drug resistance surveillance involved 1764 strains, 819 strains belong to drug resistance strains, the total drug resistance rate was 46.4% （819/ 1764）, multi drug resistance rate was 11.5% （203/1764）, extensive drug resistance rate was 1.1% （20/ 1764） . The floating population total drug resistance was 55.1% （205/372）, multi -drug resistant rate was 15.1% （56/372）, widespread drug resistant was 1.9% （7/372）, the resident population total drug resist- ance was 44. 1% （614/1392）, multi -drug resistant rate was 1.06% （147/1392）, widespread drug resistant was 0.9% （13/1392） . All the three rate above - mentioned of the former were higher obviously than that of the latter, the difference appeared significantly statistical meaning （X2are respectively 14.3, 5.8 and 2.4, all P 〈 0.05） . Conclusions The drug resistance rate of tuberculosis from floating population was dramatically higher than that of from resident population in Langfang strengthen on the basis of floating population＇s characteristics.