原发性高血压患者颈动脉粥样硬化与血清铁蛋白和同型半胱氨酸的相关性研究

The correlation study between carotid atherosclerosis and serum ferritin and homocysteine in patients with essential hypertension

目的：探讨原发性高血压（EH）患者血清铁蛋白（SF）和同型半胱氨酸（HCY）水平与颈动脉粥样硬化（CAS）的相关性.方法：以266例EH患者为研究对象,检测血清SF（电化学发光免疫法）和HCY（循环酶法）水平及颈动脉内膜中层厚度（CAIMT,彩色多普勒超声仪）,据CAIMT结果分组后进行统计学对比分析.结果：①对照组、CAIMT非增厚组及CAIMT增厚组,三组血清SF和HCY水平依次升高,且差异具有统计学意义（F=69.171、38.618,P＜0.01）.CAIMT增厚组与非增厚组血清SF和HCY水平的差异具有统计学意义（t=12.561、4.581,P＜0.01）;CAIMT非增厚组与对照组血清SF和HCY水平的差异具有统计学意义（t=6.305、2.913,P＜0.01）.②CAIMT增厚组患者血清SF和HCY水平分别与CAIMT呈正相关,其相关性良好（r=0.597、0.451,P＜0.01）.结论：EH患者体内存在着高水平的SF和HCY,血清SF和HCY水平与EH合并CAS具有相关性,联合检测血清SF和HCY水平有助于对其病情和预后的判断.

Objective：On patients with essential hypertension （EH） serum levels of serum ferritin （SF） and homocysteine （HCY） levels and the correlation of carotid atherosclerosis （CAS）. Methods ： The object of study of 266 patients with EH, detection of serum SF （electrochemiluminescence immunoassay） and HCY （circulating enzymatic） levels and carotid intima-media thickness （CAIMT, color doppler ultrasound instrument）, according to the results of CAIMT grouping after statistical comparison analysis.Results ： Normal control group and CAIMT normal group and thickening, three groups of SF and serum HCY levels increase, the difference statisticaUy significant （F = 69.171, 38.618, P 〈 0.01）. CAIMT thickening group and normal serum SF and HCY levels, statistically significant difference （r =12.561, 4.581, P 〈 0.01）. CAIMT normal group and the control group, serum SF and HCY levels statistically significant difference （t =6.305, 2.913, P 〈 0.01）. CAIMT thickening of the group of patients serum SF and HCY level, was positively related with CAIMT respectively, the correlation is good （r=0.597, 0.451, P 〈 0.01）. Conclusions ： EH patients has a high level of SF and HCY, serum SF and HCY levels associated with EH combined CAS, combined detection of serum SF and HCY levels contribute to the condition and prognosis judgement.