糖尿病足部溃疡感染病原菌分布及药物敏感性分析

Pathogen distribution and drug sensitivity analysis in diabetes mellitus patients with foot ulcer infection

目的：对糖尿病足部溃疡感染的病原菌分布情况进行分析,同时对其药物敏感性进行判断,为临床治疗过程中合理选择抗菌药物提供理论依据.方法：我院选择2011年6月～2013年6月间诊治的460例糖尿病足部溃疡患者,对其病原菌分布情况及药物敏感性进行分析.结果：本文所选的460例患者中,276株为革兰阴性菌感染,占59.0％;188株为革兰阳性菌感染,占40.2％;4株为真菌感染,占0.8％;通过对病原菌进行培养阳性率为95.22％,排在前3位的依次为金黄色葡萄球菌、奇异变形杆菌、肺炎克雷伯菌.18株超广谱β-内酰胺酶（ESBL）,为全部革兰阴性菌的6.52％,美罗培南、亚胺培南均可用于肠杆菌科细菌,头孢吡肟、阿米卡星、舒巴坦以及头孢哌酮等对铜绿假单胞菌均敏感.结论：糖尿病足部溃疡患者应早期进行微生物学检查,同时进行药敏试验以及耐药类型鉴别,高度重视耐药菌株,同时根据药敏试验结果合理选择抗菌药物,降低耐药菌株的出现.

Objective ： The distribution of the pathogen infected diabetic foot ulcers were analyzed simultaneously to determine their susceptibility to provide a theoretical basis for the clinical course of treatment a reasonable choice of antibiotics. Methods ： The hospital choice in June 2011 to 460 cases of diabetic foot ulcers among patients with diagnosis in June 2013, the distribution of pathogens and their drug sensitivity analysis.Results ： 460 cases of patients chosen for this article , the 276 Gram-negative bacterial infections, accounting for 59.0% ; 188 Grampositive bacterial infections, accounting for 40.2% ; 4 is a fungal infection , accounting for 0.8% ; by pathogens cultured positive rate was 95.22% , the top three in order of Staphylococcus aurous , Proteus mirabilis , Klebsiella pneumonia . 18 extended-spectrum [3- lantanas （ESBL）, 6.52 % of all Gram-negative bacteria, kerosene, impanel can be used for Enterobacteriaceae, caffeine, alizarin, Sheba Tan and cefoperazone against Pseudomonas aerations were sensitive. Conclusions ： Diabetic foot ulcers in patients with early microbiological examination should also be resistant to the type of identification and susceptibility testing, attaches great importance to drug-resistant strains, and selection of antibiotics based on susceptibility test results, reduce the emergence of resistant strains.