摘要
目的探讨白细胞介素1A(IL-1A)多态性与神经胶质瘤的相关性。方法采用聚合酶链反应-限制性片段长度多态性检测154例神经胶质瘤患者和195例正常对照组IL-1A多态性。结果 IL-1A+4845G/T位点:与GG基因型相比,GT/TT基因型显著增加了神经胶质瘤的发病风险(GT/TT与GG相比:χ2=5.94,P=0.015)。与G等位基因相比,T等位基因显著增加了神经胶质瘤的发病风险(χ2=5.97,P=0.015)。未发现IL-1A-889C/T多态性频率分布在对照组和神经胶质瘤组之间存在显著差异。根据神经胶质瘤病理分级进行亚组分析,未发现IL-1A-889C/T和+4845G/T多态性与病理分级存在明显相关性(P>0.05)。结论 IL-1A+4845G/T多态性与神经胶质瘤的发病有关。
Objective To investigate the association between interleukin-1A （IL-1A）polymorphisms and risk of glioma.Methods The IL-1A polymorphisms were genotyped in 154 patients with glioma and 195 healthy controls using polymerase chain reaction-restriction fragment length polymorphism assay.Results The GT/TT genotypes of IL-1A＋4845G/T polymorphism were associated with a significantly increased risk of glioma compared with the GG genotype （GT/TT vs.GG：χ^2 =5.94,P =0.015）.Similarly,the T allele of IL-1A ＋4845G/T polymorphism was associated with a significantly increased risk of glioma compared with the G allele （χ^2 =5.97,P =0.015）.There was no difference in the distribution of the IL-1A-889C/T polymorphism between cases and controls.After subgroup analysis according to histophthological grades,no significant association was observed between IL-1A-889C/T and ＋ 4845G/T polymorphisms and histophthological grades （P 〉0.05）.Conclusion IL-1A ＋4845G/T polymorphism is related to the risk of glioma.
出处
《中国实验诊断学》
2014年第9期1446-1448,共3页
Chinese Journal of Laboratory Diagnosis
