脑梗死患者检测超敏C反应蛋白和同型半胱氨酸的临床意义

Clinical significance of the levels of high-sensitive C-reactive protein and homocysteine in patients with cerebral infarction

目的:观察血清同型半胱氨酸(Hcy)和超敏C反应蛋白(hs-CRP)的变化与脑梗死患者的相关性。方法:选择脑梗死患者120例为脑梗死组,同期130名健康体检者为对照组,分别测定2组患者血清中的Hcy和hs-CRP含量,其中脑梗死合并高血压72例,非高血压患者48例。结果:脑梗死组Hcy与hs-CRP分别为(22.1±6.3)μmol/L和(9.4±2.6)mg/L,均高于对照组的(10.4±2.5)μmol/L和(1.8±0.8)mg/L(P<0.01),合并高血压组的Hcy、hs-CRP分别为(31.4±8.5)μmol/L和(13.7±4.9)mg/L,均高于非高血压组的(23.4±4.6)μmol/L和(10.7±4.3)mg/L(P<0.01)。结论:脑梗死患者血清中的hs-CRP和Hcy水平与疾病的发生、发展密切相关,联合检测hs-CRP和Hcy对脑梗死患者具有重要的临床价值。

Objective：To investigate the correlations of the levels of homocysteine（Hcy） and high-sensitive C-reactive protein（hs-CRP） and cerebral infarction. Methods：One hundred and twenty patients with cerebral infarction（ including 72 cases complicated with hypertension and 48 cases complicated without hypertension ） and 130 healthy people were divided into the experiment group and control group, respectively. The levels of Hcy and hs-CRP of all cases was detected. Results：The levels of Hcy and hs-CRP in experiment group（22. 1 ± 6. 3） mg/L and（9. 4 ± 2. 6） mg/L were higher than those in control group（10. 4 ± 2. 5） mg/L and（1. 8 ± 0. 8）mg/L（P〈0. 01）. The levels of Hcy and hs-CRP in cerebral infarction patients complicated with hypertension（（31. 4 ± 8. 5）mg/L and（13. 7 ± 4. 9） mg/L were higher than those in cerebral infarction patients complicated without hypertension（23. 4 ± 4. 6） mg/L and（10. 7 ± 4. 3） mg/L（P 〈0. 01）. Conclusions：The levels of Hcy and hs-CRP are closely related with the occurrence and development of cerebral infarction,which has importantly clinical value in cerebral infarction patients.