未足月胎膜早破产妇胎膜组织中TLR2表达变化及意义

Expression changes of TLR2 in fetal membranes of patients with preterm premature rupture of membranes and the significance

目的观察未足月胎膜早破产妇胎膜组织中Toll样受体2(TLR2)的表达变化,并探讨其意义。方法未足月胎膜早破产妇98例,产后根据病理检查结果,分为胎膜早破非炎症组(非炎症组,48例)、轻度亚临床绒毛膜羊膜炎组(轻度炎症组,17例)、中度亚临床绒毛膜羊膜炎组(中度炎症组,21例)以及重度亚临床绒毛膜羊膜炎组(重组炎症组,12例),采用免疫组化法检测各组胎膜中的TLR2。结果中、重度炎症组胎膜组织中TLR2表达高于非炎症组,且重度炎症组>中度炎症组>轻度炎症组(P均<0.05)。结论未足月胎膜早破合并亚临床绒毛膜羊膜炎产妇胎膜组织中TLR2表达上调,与其发病有关。

Objective To observe the expression changes of toll-like receptor 2 （ TLR2） in fetal membranes of patients with preterm premature rupture of membranes （ PPROM） and to investigate the significance .Methods Ninety-eight cases of PPROM women were enrolled .According to the pathological test results , they were divided into non-inflamed PPROM group （non-inflamed group, n=48）, mild subclinical chorioamnionitis group （mild inflammation group, n=17）, moderate subclinical chorioamnionitis group （ moderate inflammation group , n=21 ） and severe subclinical chorioamnionitis group （severe inflammation group, n=12） group.The expression of TLR2 in fetal membranes was determined by immunohistochemistry in each group .Results The expression of TLR2 in the moderate and severe inflammation groups was higher than that of the non-inflamed group , severe inflammation group ＆gt;moderate inflammation group ＆gt;severe inflammation group （all P＆lt;0.05）.Conclusions The expression of TLR2 is up-regulated in PPROM women with subclinical chorioamnionitis, which is associated with its pathogenesis .