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难治性肾病综合征患者尿miRNA-192、miRNA-29c表达及意义 被引量：4

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摘要 目的探讨尿miRNA-192、miRNA-29c在难治性肾病综合征(RNS)患者尿液中的表达及意义。方法选择RNS患者44例,包括局灶节段硬化肾小球肾炎(FSGS)20例(FSGS组)、膜性肾病(MN)6例(MN组)、系膜增生性肾小球肾炎(MsPGN)18例(MsPGN组),健康对照组15例为健康志愿者。采用RT-PCR法检测四组尿液miRNA-192、miRNA-29c的表达。结果 MsPGN组miR-192表达水平高于健康对照组(P<0.05)。FSGS组miR-29c表达水平低于健康对照组(P<0.05)。结论 RNS患者尿miR-192表达增高、miR-29c表达降低,尿miRNA-192、miRNA-29c检测有助于判断肾小球细胞外基质蓄和及肾间质纤维化的程度,可作为辅助判定RNS病理类型的检测指标。
作者 张春花 王明 耿振波 魏连波 于淑军
机构地区 南方医科大学珠江医院 威海市中医院
出处 《山东医药》 CAS 2014年第22期38-39,共2页 Shandong Medical Journal
基金 广东省科技技术厅-广东省中医药科学院联合科研专项项目(2011B03220001)
关键词 肾病综合征 RNA 小分子干扰 尿液
分类号 R692.3 [医药卫生—泌尿科学]
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参考文献8

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二级参考文献18

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山东医药
2014年 第22期

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