中心点设计法优化细辛脑乳剂的旋转蒸发工艺

Optimization of the Rotary Evaporation Process of Asarone Emulsion by Central Composite Design

目的筛选细辛脑乳剂旋转蒸发工艺的参数条件,提高制剂质量,并对优化条件可行性进行预测。方法采用中心点设计法优化细辛脑乳剂的旋转蒸发工艺,自变量为进料速率,加热温度,转速及真空度,以甲醇及氯仿的去除率,收率,平均粒径及有关物质为因变量,对各水平的自变量进行多元线性回归和拟合,选择较佳工艺条件。结果甲醇及氯仿的去除率、收率、总杂质模型拟合较好,相关系数r分别为0.9306、0.95123、0.8465、0.9752,预测值与实测值的RSD%均小于2%。结论效应面优化法具有试验次数少,精确度高,使用方便,优选条件预测性好等特点。

OBJECTIVE To screen the parameters of the rotary evaporation process of Asarone emulsion,improve the quality of preparations and forecast the predictive optimization conditions. METHODS The central composite design method was used to optimize the rotary evaporation process of Asarone emulsion. For the feed rate,temperature,speed and vacuum degree as the independent variables,the removal of methanol and chloroform,yield,average particle size and the related substance as dependent variables,multiple linear regression equation and fitting was set up for independent variables in every level and the better technology conditions was choosed. RESULTS The model of the removal rate of methanol and chloroform,yield,total impurity had good fitting,the correlation coefficient r were 0. 9306,0. 95123,0. 8465,0. 9306,RSD% of the predicted values and the measured values was less than 2%. CONCLUSION The Design-Response Surface Method has the characteristic of fewer tests,high precision,easy to use,and good predictive optimization conditions.