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白细胞介素-4及其受体的研究现状 被引量：9

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摘要 白细胞介素-4（interleukin-4，IL-4）是域型辅助T细胞（Th2细胞）分泌的细胞因子。人类白细胞介素-4受体（interleukin-4 receptor，IL-4R）属于红细胞生成素受体超家族成员，与IL-4特异性结合后发挥其生物学功能，现已发现有可溶性IL-4R（Solu-bleinterleukin-4 receptor，sIL-4R）及膜型IL-4R （murine interleukin-4 receptor，mIL-4R），两者与IL-4的结合时的亲和力相同。其中sIL-4R可作为IL-4的保护性载体，并且具有调节IL-4生物学活性的功目前，临床上将IL-4及其受体作为免疫调节剂，在检测和防治哮喘、类风湿性关节炎和肿瘤等相关疾病的效果已经日渐显著。笔者以IL-4及IL-4R对有关文献进行查阅、整理和归纳。现将介绍IL-4及其受体研究现状如下。
作者 杨光勇 郭海涛 何光志
机构地区 贵阳中医学院
出处 《浙江中西医结合杂志》 2014年第9期843-845,共3页 Zhejiang Journal of Integrated Traditional Chinese and Western Medicine
基金 贵州省社会发展科技攻关项目[黔科合SY字(2011)3020] 贵州省委组织部高层次人才科研条件特助经费项目(TZJF-2011年28号)
关键词 IL-4 研究现状
分类号 R346 [医药卫生—基础医学]
  • 相关文献

参考文献33

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二级参考文献53

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共引文献75

同被引文献71

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引证文献9

二级引证文献17

浙江中西医结合杂志
2014年 第9期

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