12例HIV/AIDS并发活动性结核患者临床分析

Study of clinical characters in patients of acquired immune deficiency syndrome with TB infections

目的:分析HIV/AIDS并发活动性结核感染患者的临床特点,探讨HIV并发结核的发生与患者免疫状态的相关性,为做好HIV/AIDS并发活动性结核患者的治疗与管理提供科学依据。方法:回顾性分析12例HIV/AIDS并发活动性结核患者的病例资料,对临床表现、CD4+T淋巴细胞、PPD、ESR、TBAb及结核蛋白芯片等实验室检查结果进行分析,将所有资料数值用EXCEL建立数据库。结果:本研究共收集HIVAIDS并发活动性结核患者12例,HIV合并结核患者临床表现多样,以体重减轻和发热为主;男女患病率1.4∶1,中位年龄(41.25±8.23)岁,感染途径多以血液及性传播为主;实验室检查PPD、ESR、TBAb及结核蛋白芯片阳性率较低;HIV/AIDS并发活动性结核感染时患者的CD4+T淋巴细胞显著减少,均值为(134.8±153.4)×106/L。结论:HIV/AIDS并发活动性结核患者临床表现多样,免疫力低下,应加强对这类患者的筛查。

Objective： To investigate the clinical characters in acquired immune deficiency syndrome patients with TB infections. Method.. 12 cases of AIDS/TB patients were enrolled in the study and analyzed retrospectively. Result：The clinical manifestations in 12 HIV/AIDS with TB infections were fever and loss of weight. The ratio of male to female is 1.4 ： 1 and the median age is（41.25±8.23） years old. The main route of transmission is by blood and sex. Patients have a serious immune deficiency during diagnosing, the median count of CD4＋ T cells is （134. ±153.4）×10^6/L. Conclusion： HIV/TB had various clinical manifestations. They were in the late stage of HIV/AIDS. More attention should be given to those patients.