基底细胞样乳腺癌组织Apaf-1蛋白表达临床意义

Expression of Apaf-1 in basal-like breast carcinoma and its clinical significance

目的检测凋亡蛋白酶活化因子(Apaf-1)在基底细胞样乳腺癌(BLBC)中的表达,分析Apaf-1与BLBC临床病理特征的关系。方法采用免疫组化方法检测43例BLBC、57例non-BLBC和60例癌旁正常乳腺组织中Apaf-1蛋白的表达。结果免疫组化检测结果显示,在BLBC及non-BLBC中Apaf-1的表达的阳性率分别为23.26%和49.12%,明显低于癌旁正常乳腺组织的75.00%,差异均有统计学意义(P<0.05);Apaf-1的表达与患者年龄无关,与BLBC淋巴结转移、肿瘤大小及临床分期负相关(P<0.05)。结论 BLBC组织低表达Apaf-1,Apaf-1可能与BLBC的发生、发展密切相关。

Objective To detect and analyze the expression of Apaf-1 in basal-like breast cancer （BLBC） and correlation between Apaf-1 expression and clinicopathology features of BLBC . Methods The expression of Apaf-1 was detected in 43 cases of BLBC, 57 cases of non-BLBC and 60 cases of normal breast tissue by immunohistochemistry. Results The positive rate of Apaf-1 in BLBC and non-BLBC group were 23.62% and 49.12%, respectively, which were much lower than that in normal breast tissue （75.00%）（P〈0.05）.The expression of Apaf-1 wasn＇t negatively correlated with age, but it was correlated with lymph nodes metastasis, tumor size and pTNM staging of BLBC（P〈0.05）.Conclusion The expression level of Apaf-1 is lower and might be correlated with the carcinogenesis and development of BLBC.