瑞舒伐他汀对急性冠状动脉综合征合并心律失常患者血脂和炎症因子的调节作用研究

Influence of rosuvastatin on blood lipids and inflammatory factors in patients combined with acute coronary syndrome and arrhythmia

目的探讨瑞舒伐他汀对急性冠状动脉综合征(ACS)合并心律失常患者血脂和炎症因子的调节作用。方法于2010年2月至2012年12月,将102例ACS合并心律失常患者分为A组和B组,每组患者51例。A组给予瑞舒伐他汀组治疗,B组给予阿托伐他汀治疗。比较两组患者治疗前后低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、白细胞介素-18和C反应蛋白水平。结果两组患者治疗后血脂及炎症指标水平与治疗前比较差异均有统计学意义,且治疗后A组血脂及炎症指标改善程度均较B组更为明显(P<0.05)。结论瑞舒伐他汀对ACS合并心律失常患者体内脂代谢水平和炎症状态均有一定的调节作用,可用于ACS合并心律失常患者的临床治疗。

Objective To explore the influence of rosuvastatin on blood lipids and inflammatory factors in patients combined with acute coronary syndrome（ACS）and arrhythmia.Methods During Feb.2010 and Dec.2012,a total of 102 patients combined with ACS ad arrhythmia were divided into group A,receiving treatment of rosuvastatin,and group B,receiving treatment of atorvastatin,with 51 case for each group.Levels of low density lipoprotein cholesterol,high density lipoprotein cholesterol,interleukin-18 and C-reactive protein were compared before and after treatment.Results Levels of all indictor in both groups,detected after treatment,were significantly different with those detected before treatment,and the improvement of all indicators in group A was more obvious than group B（P〈0.05）.Conclusion Rosuvastatin could regulate levels of blood lipids and inflammatory in patients combined with ACS and arrhythmia,which might be fit for clinical application.