调节性T细胞与内分泌疾病

Regulatory T Cells and Endocrine Diseases

调节性T细胞(Treg)是一群有调节功能的T细胞亚群,其具有免疫调节和抑制功能。CD4+CD25+Treg是Treg亚群的重要组分,Foxp3是其特征性细胞表面标志物。近年的研究认为,Treg与自身免疫性疾病密切相关,内分泌疾病的发生可能与Treg的数目及功能异常有关。该文就Treg与骨质疏松症、1型糖尿病、自身免疫性甲状腺疾病等内分泌疾病的关系进行综述。

Regulatory T cells（Treg） are subsets of T cells,with immune regulating and inhibiting function.CD4 ＋ CD25 ＋ Tregs are the main components of Treg subset.Forkhead box P3（Foxp3） is a characteristic cell surface marker of Treg.Increasing number of reports reveal that there was a close relationship between Treg and autoimmune diseases in recent years.The pathology of some endocrine diseases maybe due to the abnormal proportion and function of Treg.Here is to make a review of the relationship between Treg and osteoporosis type 1 diabetes and autoimmune thyroid disease etc.