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上皮-间质转化在肿瘤多药耐药性发生中的作用

Roles of Epithelial-Mesenchymal Transitions in Multidrug-resistant Tumor
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摘要 化学治疗是肿瘤综合治疗的重要方法之一,而多药耐药一直是导致肿瘤化学治疗失败的主要原因。上皮-间质转化(EMT)是正常发育、伤口愈合的基础,同时也在肿瘤发生、侵袭及转移过程中发挥着重要作用,近年来越来越多的研究证实EMT也参与了肿瘤多药耐药的发生。该文主要就EMT的概念、发生机制及其在肿瘤多药耐药过程中机制的研究进展进行综述。 Chemotherapy is one of the most important ways to the treatment of tumor,while muhiple drug resistance is a major cause of failure in tumor chemotherapy.Epithelial-mesenchymal transitions（EMT） are the basis of normal development and wound healing and also play an important role in tumor resistance to muhiple drugs.Here is to make a review of the concept and mechanism of EMT,and its roles in muhidrugresistant Tumor.
作者 肖欣悦 库雯静 魏柯 叶佳园 刘庆昌 郭琳琅
机构地区 南方医科大学第二临床医学院 南方医科大学珠江医院病理科
出处 《医学综述》 2014年第18期3304-3306,共3页 Medical Recapitulate
基金 国家级大学生创新创业训练计划项目(201212121017)
关键词 上皮-间质转化 肿瘤 多药耐药性 Epithelial-mesenchymal transitions Tumor Multiple drug resistance
分类号 R364.5 [医药卫生—病理学] R730.22 [医药卫生—肿瘤]
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参考文献29

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医学综述
2014年 第18期

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