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Th17和Treg在心血管疾病中作用的研究进展 被引量：2

Study on the Roles of Th17 and Treg in Cardiovascular Disease
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摘要 辅助性T细胞17(Th17)和CD4+CD25+调节性T细胞(Treg)是两类不同于Th1和Th2的CD4+T淋巴细胞。Th17具有极强的促炎症作用,Treg可有效地调控自身免疫性疾病并维持自身免疫耐受。两者的平衡对维持内环境稳定起着重要的作用,失衡则可能引起免疫应答异常,并与多种疾病发生、发展密切相关。近年来随着对两者研究的不断深入,其在心血管系统中的作用逐渐引起人们的关注。 T-helper 17 cells（Th17） and CD4 ＋ CD25 ＋ regulatory T cells（Treg） are two original subsets of lymphocytes distinguished from Th1 and Th2 cells.Th17 has strong pro-inflammatoU effects.Treg can control autoimmune diseases and maintain immune tolerance effectively.The balance of Th17 and Treg plws important roles in homeostasis,while their imbalance m cause dysimmunity.Here is to make a review of the functions of Th17 and Treg in cardiovascular disease.
作者 王天娇 赵孟 尹新华
机构地区 哈尔滨医科大学附属第一医院心血管内科
出处 《医学综述》 2014年第18期3341-3343,共3页 Medical Recapitulate
关键词 辅助性T细胞17 调节性T细胞 白细胞介素17 心血管疾病 T-helper 17 cells Regulatory T cells Interleukin 17 Cardiovascular disease
分类号 R331.144 [医药卫生—人体生理学] R714.252 [医药卫生—妇产科学]
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参考文献25

  • 1Komiyama Y,Nakae S,Matsuki T,et al.IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis[J].J Immunol,2006,177(1):566-573.
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二级参考文献10

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医学综述
2014年 第18期

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