2型糖尿病患者T波峰末间期与室性心律失常的影响因素分析

Regression Analysis between Tpeak-Tend Interval and Ventricular Arrhythmias in Patients with Type 2 Diabetes Mellitus

目的了解2型糖尿病(T2DM)患者的Tp-Te间期离散(Tp-Ted)的变化,为预测心血管危险事件的发生提供依据。方法将2011年2月至2013年6月广西壮族自治区人民医院内分泌代谢科收治的60例T2DM患者与60例健康对照组的Tp-Ted进行比较,并分析Tp-Ted与室性心律失常的影响因素。结果 T2DM组患者的Tp-Ted较对照组显著延长(P<0.01),室性心律失常发生率显著升高(P<0.05)。空腹血糖、糖化血红蛋白增高是Tp-Ted延长的危险因素(P<0.01);Tp-Ted延长易诱发室性心律失常(P<0.01)。结论血糖的增高会加重心肌电活动的不稳定性,易诱发心血管危险事件。

Objective To understand the changes of Tpeak-Tend Interval（Tp-Ted）in patients with type 2 diabetes,provide the basis for predicting the risk of cardiovascular events.Methods A total of 60 patients with type 2 diabetes and 60 healthy controls from People＇s Hospital of Guangxi Zhuang Autonomous Region from Feb.2011 to Jun.2013were included,and Tp-Ted of the two groups were compared and the influencing factors for Tp-Ted and ventricular arrhythmias were analyzed.Results Tp-Ted of diabetic patients were significantly longer than the control group（P 〈 0.01）,ventricular arrhythmias incidence was increased significantl（P 〈 0.05）.Elevated fasting plasma glucose and glycated hemoglobin were risk factors to lead Tp-Ted prolongation （P 〈 0.01） ; prolonged Tp-Ted could induce ventricular arrhythmias more easily（P 〈 0.01）.Conclusion Elevated blood glucose increases the instability of cardiac electrical activity,and induces cardiovascular events.