唑来膦酸影响骨密度效果的系统评价

Effectiveness of Zoledronic Acid Increasing Bone Mineral Density: A Systematic Review

目的系统评价唑来膦酸影响骨密度的临床效果。方法计算机检索Cochrane Ce4ntral Register of Controlled Trials,OTA,AAOS,High Wire Press,Springer Link,MEDLINE,EMBASE,CINAHL,ISI Web of Science,CNKI,VIP,万方数据库和中国生物医学文献数据库(CBM)并辅以手工检索关于唑来膦酸影响骨密度的随机对照试验(RCT)。结果共纳入7个RCT。3个RCT显示唑来膦酸可增加腰椎骨密度增加率,3个RCT显示唑来膦酸可增加股骨颈骨密度增加率,4个RCT显示唑来膦酸可增加腰椎骨密度。结论唑来膦酸对增加全身多处骨密度有一定效果。

Objective To evaluate the effectiveness of zoledronic acid increasing bone mineral density （BMD）.Methods The Cochrane Central Register of Controlled Trials,OTA,AAOS,High Wire Press,Springer Link,MEDLINE,EMBASE,CINAHL,ISI Web of Science,CNKI,VIP,Wan fang Data,CBM were searched by computer and hand for randomized controlled trials（RCT） of zoledronic acid influencing the BMD.Results Seven RCTs were included.Three studies indicated that zoledronic acid improved lumbar spine BMD increasing-rate.Three studies indicated that zoledronic acid improved femoral neck BMD increasing-rate.Four studies indicated that zoledronic acid increased lumbar spine BMD.Conclusion Zoledronic acid is effective in increasing bone mineral density of muhiple parts of the body.