hs-CR、TNF-α、MDA、SOD在主动脉夹层中的应用价值

The Application Value of hs-CRP,TNF-α,MDA,SOD in Aortic Dissection

目的分析超敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)、丙二醛(MDA)、超氧化物歧化酶(SOD)在主动脉夹层(AD)中的临床价值。方法选择2010年1月至2013年10月在解放军总院及保定市级医院住院的初发AD患者36例作为AD组。Stanford分类:A型主动脉夹层12例(AAD组),B型主动脉夹层24例(BAD组)。选择同期进行健康体检的30例健康就诊者作为对照组,检测两组受试者及不同Stanford分类患者的CRP、TNF-α、MDA、SOD水平,并分析4种指标在AD患者诊断及预后判断中的应用价值。结果 AD组患者hs-CRP、TNF-α、MDA水平显著高于对照组,SOD显著低于对照组,差异有统计学意义(P<0.01);AD组病死者hs-CRP、TNF-α、MDA水平显著高于存活者,SOD水平显著低于存活组,差异有统计学意义(P<0.01)。结论 CRP、TNF-α、MDA、SOD对AD的诊断及预后的判断有一定的临床价值。

Objective To analyze the clinical value of hypersensitive C-reactive protein（hs-CRP）,tumor necrosis factor-α（TNF-α）,malondialdehyde（MDA）,superoxide dismutase（SOD） in aortic dissection （AD）.Methods A total of 36 patients with early onset AD from PLA General Hospital and Baoding Municipal Hospital during Jan.2010 and Oct.2013 were included as AD group.,and were subdivided accoMing to Stanfod classification：12 cases of aortic dissection type A （AAD group）,24 cases of aortic dissection type B（BAD group）.30 cases of healthy persons for health check-up during the same period were included as a control group.CRP,TNF-α,MDA,SOD levels of the two groups were tested,and the application value of the 4 indexes for the diagnosis and prognosis of AD was analyzed.Results hs-CRP,TNF-α,MDA levels of AD patients were significantly higher than the control group,SOD level was significantly lower than the control group,the difference was statistically significant（P 〈 0.01）.hs-CRP,TNF-α,MDA levels of the death in AD group were significantly higher than the suivors,and SOD level was significantly lower than the survivors,the differences were statistically significant（P 〈 0.01）.Conclusion Serum CRP,TNF-α,MDA,SOD level have a certain clinical value for the diagnosis and prognosis of AD patients.