早发性小儿癫痫临床特征和脑电图变化研究

Clinical Features and EEG Changes of Early-onset Epilepsy

目的探讨早发性小儿癫痫的临床特征和脑电图变化情况。方法回顾性分析2009年7月至2013年7月枣庄市立医院收治的310例不同年龄的早发性小儿癫痫患者的临床特征及脑电图检查结果,采用型号为PI400A-B的动态脑电图仪对各年龄段的脑电图分级以及各年龄段波型与异常脑电图进行对比分析。结果各年龄阶段脑电图异常率差异均无统计学意义(P>0.05)。各年龄阶段在散发或阵发慢波增多、尖波、棘波、尖(棘)慢综合波以及双侧显著不对称发生率的差异均无统计学意义(P>0.05),但是在暴发性抑制发生率方面的差异有统计学意义(P<0.05)。结论早发性小儿癫痫在各年龄阶段的异常率及脑电图在暴发性抑制发生率方面均有差异性,且符合其临床发病特点;不同类型的小儿癫痫均具有各自对应的药物,经治疗均有显著性效果。

Objective To investigate the clinical features and EEG changes of the early-onset epilepsy.Methods Retrospective analysis of clinical features and EEG findings of 310 children patients of different ages with early onset epilepsy treated in Zaozhuang City Hospital from Jul.2009 to Jul.2013 was done.PI400A-B ambulatory EEG was used for EEG classification of all ages and wave EEG abnormalities were analyzed.Results The abnormal EEG rates of different age groups were not statistically significant（P 〉 0.05）.The distribution or increased paroxysmal slow,sharp waves,spikes,sharp （spine） slow wave complex and significant bilateral asymmetry of different age groups were not statistically significantly different（P 〉 0.05）,but in fulminant suppress the incidence difference was statistically significant（P 〈 0.05）.Conclusion Early-onset epilepsy abnormality rate and EEG in children of all ages all have differences,which are in accordance with the clinical features of the disease.Different types of epilepsy in children all have their corresponding drugs with significant effects shown after treatment.