新的金刚烷酰腙衍生物的微波合成及结构表征

Microwave-assisted synthesis and structural characterization of novel adamantaneacylhydrazone derivatives

以1-金刚烷甲酸为起始原料,利用微波辐射无溶剂法,设计合成了9个金刚烷酰腙衍生物,并利用1H NMR、ESI-MS、IR和元素分析对其结构进行了确认.通过微波法和常规法的对比发现,使用微波法后,反应产率从70%～80%升高到90%～95%,反应时间从2.0～3.5 h缩短到1.0～3.0 min.

Nine novel adamantaneacylhydrazone derivatives were synthesized in the solvent-free condition under microwave irradiation by using 1-adamantanecarboxylic acid as starting material. Compared with a conventional method, the yield was increased from 70%～ 80% to 90%～95% and the reaction time was reduced from 2.0～ 3.5 h to 1.0～ 3.0 min. The structures of the new compounds are confirmed by 1H NMR, ESI-MS spectra, IR and element analyses.