自制中药油外涂预防放射性皮肤损伤的效果观察

Effects of self-made traditional Chinese medicine oil in prevention of radiation-induced skin injury

目的：观察自制中药油外涂预防放射性皮肤损伤的效果。方法将99例接受放射治疗的头颈部肿瘤患者按随机数字法分为A组（34例）、B组（33例）、C组（32例）。照射前，A组用自制中药油外涂于照射野皮肤上，照射后继续用药3 d，3次/d，直至放疗结束；B组采用医用射线防护喷剂；C组采用湿润烧伤膏。B组和C组的用药方法均同A组。结果 A组放射性皮肤损伤的发生率为14.7%，B组为21.2%，C组为46.9%，A、B两组之间的差异无统计学意义（χ2＝0.4822，P〉0.05）；A、C两组之间的差异有统计学意义（χ2＝8.0772，P＜0.01）；B、C两组之间的差异有统计学意义（χ2＝4.7786，P＜0.05）。结论自制中药油对放射性皮肤损伤的预防效果同医用射线防护喷剂，明显优于湿润烧伤膏，具有疗效好、操作简单、方便等优点，且价格明显低于医用射线防护喷剂，值得推广应用。

Objective To observe the effects of self-made traditional Chinese medicine oil in prevention of radiation-induced skin injury. Methods Ninety-nine head and neck neoplasm patients who received radiotherapy were divided randomly into three groups： group A（34 cases）, group B（33 cases） and group C （ 32 cases ） . Before radiation , group A was treated with self-made traditional Chinese medicine oil directly applied on the exposure field skin. After radiation , such medicine oil was continued to apply for three days at a frequency of three times a day till the end of the radiotherapy; group B was treated with medical radiation protection spray;group C was treated with moisture exposed burn ointment. The methods applied on group B and group C were the same as that of the group A. Results The inci-dence rate of radiation-induced skin injury of group A was 14.7%;while the incidence rate was 21.2%for group B and 46.9%for group C. The difference between group A and group B beard no statistical signifi-cance（χ2=0.4822, P〉0.05）; while there were statistically significant differences between group A and group C（χ2=8.0772, P＆lt;0.01）, group B and group C（χ2=4.7786, P＆lt;0.05）. Conclusions The self-made traditional Chinese medicine oil has similar preventive effect to medical radiation protection spray on radi-ation-induced skin injury and is obviously superior to moisture exposed burn ointment. And self-made tra-ditional Chinese medicine oil is featured by satisfying curative effect, easy operation, convenient han-dling, etc. Because of the lower price, the self-made traditional Chinese medicine oil is more suitable for application than the medical radiation protection spray.