IVF-ET周期中高龄卵巢低反应患者不同受精方式的妊娠结局分析

Pregnancy Outcomes of Different in Vitro Fertilization Methods in Older Patients IVF-ET Cycles with Poor Ovarian Response

目的:比较常规体外受精(IVF)和胞浆内单精子注射(ICSI)2种受精方式对无明确男性因素的高龄卵巢低反应患者治疗结局的影响,探讨这类患者合适的受精方式。方法:回顾性分析IVF-胚胎移植(ET)周期中高龄(年龄≥40岁)卵巢低反应周期共381个,按受精方式分为常规IVF组(200个周期)与ICSI组(181个周期),分析比较2组间的受精率和临床结局。结果:IVF组的受精率和移植周期临床妊娠率略高于ICSI组,ICSI组的有效周期率和有效胚胎率略高于IVF组,但差异均无统计学意义(P>0.05)。结论:无明确男性因素的高龄卵巢低反应患者,ICSI受精并不能提高其受精率和临床妊娠率。

Objective： To compare the efficacy of conventional in vitro fertilization （IVF） and intracytoplasmic sperm injection （ICSI） in older patients with poor ovarian response. Methods： The data of 381 in vitro fertilization-embryo transfer （IVF-ET） cycles of older patients （≥40 years old） with poor ovarian response were analyzed retrospectively. Those cycles were divided into two groups ：IVF group（conventional IVF, 200 cycles） and ICSI group （181 cycles）. Fertilization rate and clinical pregnancy rate were compared between two groups. Results： The fertilization rate and clinical pregnancy rate in the IVF group were insignificantly higher than those in the ICSI group ,while the rate of effective cycles and high quality embryos in the ICSI group were very limitedly higher than those in the IVF group. However, there were not statistically differences in those rats between two groups （P〉0.05）. Conclusions： ICSI treatment did not increase fertilization rate and clinical pregnancy rate in IVF-ET cycles in those patients at ≥40 years with poor ovaian response.