连理汤加味对活动期溃疡性结肠炎IL-33表达的影响及临床疗效

The Clinical Efficacy and the Influence of the IL-33 Expression on the Active Ulcerative Colitis with Lianlitang Decoction

目的:探讨连理汤加味对活动期溃疡性结肠炎患者IL-33表达的影响及临床疗效,以期阐明连理汤加味对活动期溃疡性结肠炎的作用机制。方法:选取84例活动期溃疡性结肠炎患者,随机分为对照组和治疗组,对照组给予美沙拉嗪缓释颗粒剂进行治疗,治疗组在常规治疗的基础上辨证使用连理汤,考察IL-33表达及临床疗效。结果:对照组总有效率为78.6%,治疗组为95.2%,治疗组总有效率明显高于对照组,具有显著性差异(P<0.05);对照组与治疗组血清中IL-33的含量较治疗前均出现了明显的上升,具有显著性差异(P<0.05);治疗组IL-33的含量较对照组上升更明显,具有显著性差异(P<0.05);两组均未出现严重的不良反应。结论:在常规治疗的基础上,辨证使用连理汤对活动期溃疡性结肠炎患者进行治疗,可影响IL-33表达,提高临床治疗效果,且安全性良好,具有较大的临床意义。

Objective： Investigate the effect and clinical efficacy with Lianlitang decoction of active ulcerative colitis in IL- 33 expression,Clarify the mechanism of action. Methods： 84 cases of active ulcerative colitis patients were randomly divided into a control group and the treatment group and the control group received mesalazine enteric- coated tablets for treatment,the treatment group using dialectical soup with management on the basis of conventional therapy,IL- study 33 expression and clinical efficacy. Results： The total effective rate was 78. 6% in the treatment group was 95. 2%,the total efficiency of the treatment group was significantly higher,with a significant difference（ P〈0. 05）; levels in the control group and the treatment group,the serum IL- 33 before treatment were shown a significant rise,with a significant difference（P〈0. 05）; content of IL- 33 in the treatment group compared with the control group rose more obvious,with a significant difference（P〈0. 05）; groups no serious adverse reactions. Conclusion： On the basis of conventional therapy,dialectical soup even the rationale for the use of active ulcerative colitis treatment,can affect the expression of IL- 33 to improve clinical outcomes and good security,with greater clinical significance.