Lox-1——心血管疾病防治的新靶标

Lox-1,a new target in cardiovascular disease

目的 Lox-1(血凝素样氧化低密度脂蛋白受体1),是ox-LDL的主要受体之一,在血管内皮功能障碍、泡沫细胞形成及动脉粥样硬化斑块的稳定性中具有重要作用。方法为了探讨Lox-1在心血管疾病中的作用,笔者对有关Lox-1在心血管疾病中的研究进展进行回顾性分析。结果 Lox-1作为ox-LDL新型清道夫受体,在心血管疾病的发生发展中具有重要的作用。结论 Lox-1可能为防治心血管疾病的药物研究提供新的思路。

Objective Lox-1（ lectin-like oxidized low-density lipoprotein receptor-1） was one of the main receptor of oxLDL,which took an important role in vascular endothelial dysfunction,the formation of foam cells,and the stability of atherosclerotic plaques. To investigate the role of Lox-1 in cardiovascular diseases. Methods The literatures of Lox-1 in cardiovascular diseases retrospectively were reviewed. Results As a new ox-LDL scavenger receptor,Lox-1 played an important role in cardiovascular diseases.Conclusion Lox-1 might provide new ideas for cardiovascular diseases.