上海市浦东新区2013年手足口病检测结果分析

Analysis the Examination Results of Foot-Hand-Mouth Disease in Pudong New District of Shanghai, 2013

目的 了解2013年上海市浦东新区手足口病与2012年流行情况的差异,为2014年的手足口病预防与监测提供实际依据.方法 实时荧光PCR方法检测2013年上海市浦东新区手足口病病例标本293份.结果 293例病例样本中,肠道病毒检出率为59.39％,明显高于2012年,其中EV 71占21.39％、Cox A16占19.08％、Cox A6占38.73％、Cox A 10占2.31％,其他肠道病毒占18.50％.手足口病全年在本区均出现不同程度的流行,6月份为流行高峰月,检出率为58.18％.高发年龄为2～5岁儿童,占阳性总数的82.08％,且男性多于女性（男∶女=1.60∶1）.聚集性暴发病例占50.32％,主要发生在幼托机构,其余均为散居儿童.结论 Cox A6已成为2013年上海市浦东新区手足口病流行的重要病原,建议实验室进一步对未分型肠道病毒进行检测.

OBJECTIVE To know difference of the epidemiological and etiological characteristics of Hand- Foot-Mouth Disease （HFMD）between 2013 and 2012 in Pudong New District of Shanghai. To provide lab basisfor the FHMD control and prevention. METHODS 293 samples were collected from the HFMD patients. Samples were detected by real-time PCR for enteroviris 71, coxsackie 6, coxsackie 10 and coxsackie 16. RESULTS The detection rate of HFMD was 59.25%, which was higher than that of 2013. The constituent ratio of EV71, CAI6, CA6, CA10 and other enterovirus were 21.39%, 19.08%, 38.73%, 2.31% and 33.66%, respectively. HFMD was prevalent all the year and the epidemic peak was in June. Children from 2 to 5 were easy to catch the HFMD in the kindergarten. The male to female ratio of the positive cases was 1.60：1. CONCLUSION CA6 was the main subtypes to cause the HFMD in Pudong New District of Shanghai in 2013. It is suggested that the surveillance and detection new subtypes of HFMD should be enhanced.