期刊文献+

左卡尼汀对围手术期老年高血压病患者血清CK-MB和cTnI水平的影响 被引量:2

下载PDF
导出
摘要 目的:探讨左卡尼汀对围手术期老年下肢骨折高血压病患者血清肌酸激酶同功酶( CK-MB)和肌钙蛋白I(cTnI)水平的影响。方法将围手术期、ASAⅡ~Ⅲ级、老年(≥65岁)高血压患者120例,随机分为治疗组与对照组各,60例。术前2天每天早晨治疗组静滴左卡尼汀3.0 g(溶于生理盐水100 mL中);对照组静滴等量生理盐水。于用药前、麻醉前、术始2 h、术后5 h、术后24 h五个时间点抽取静脉血5 mL测定CK-MB、cTnI,比较两组CK-MB水平和cTnI阳性率。结果治疗组术始2 h、术后5 hCK-MB水平低于对照组(P<0.05);术始2 h、术后2 h、术后24 h cTnI阳性率低于对照组(P<0.05)。结论左卡尼汀对围手术期老年高血压病患者心肌具有保护作用。
出处 《山东医药》 CAS 2014年第26期63-64,共2页 Shandong Medical Journal
  • 相关文献

参考文献9

  • 1Marsch SC, Schaefer HG, Skarvan K, et al. Perioperative myocardial ischemia in patients under going elective hiparthru plasty during lumbarregional anesthesia l J'l Anesthesiology, 1992,76 (4) : 518- 527.
  • 2Helton E, DUITagh R, Francis P, et al. Metabolic aspects of myocardial disease and a role of L-carnitine in the treatment of children cardiomyopathy [J]. Pediatrics, 2000,105 (6) : 1260-1270.
  • 3lyer RN, Khan AA, Gupta A, et al. L-carnitine moderately improves the exercise tolerance in chronic stable angina [J]. J Assoc Physicians India, 2000,48( 11) :1050.
  • 4Losterh, Miehe K, Punzel M, et aI. Prolonged oral L-carnitine substitution increases bicycle ergometer performance in patients with severe, ischemically induced cardiac insufficiency [J] . Cardiovasc Drugs Ther, 1999,13(6) :537-546.
  • 5Bodor GS, Porterfield D, Voss EM, et aI. Cardiac troponin I is not expressed in fetal and healthy or disease adult human skeletal muscle tissue] J]. Clin Chern, 1995,41 (12 Pt 1) : 1710-1715.
  • 6屠伟峰,戴建强.非心脏手术老年患者围术期心肌缺血的预测和防治[J].临床麻醉学杂志,2003,19(7):434-436. 被引量:17
  • 7李亚萍,郭丽君,张福春,李昭屏,高炜.左旋卡尼汀对急性心肌梗死经皮冠状动脉介入治疗患者的心肌保护作用[J].中国介入心脏病学杂志,2006,14(4):195-197. 被引量:13
  • 8徐纪光,张守林,高素琴.心肌肌钙蛋白的特点及临床应用[J].山东医药,2003,43(4):65-66. 被引量:1
  • 9曾凯宏,刘韧,代惊,刘玉兰.心肌肌钙蛋白检测方法的研究进展[J].新医学,2004,35(1):59-60. 被引量:25

二级参考文献25

  • 1Marsch SC, Schaefer HG, Skarvan K, et al. Perioperative myocardial ischemia in patients undergoing elective hip arthroplasty during lumbar regional anesthesia. Anesthesiology, 1992,76: 518-527.
  • 2Munzer T, Stimming G, Brucker B, et al. Perioperative myocardial infarction and cardiac complications after noncardiac surgery in patients with prior myocardial infarction. I. Clinical data and diagnosis,incidence. Anaesthesist, 1996,45 : 213-220.
  • 3Mangano DT, Browner WS, Hollenberg M, et al. Association of perioperative myocardial ischemia with cardiac morbidity and mortality in men undergoing noncardiac surgery. N Engl J Med,1990,323:1781-1788.
  • 4Hollenberg M, Mangano DT, Browner WS,et al. Predictors of postoperative myocardial ischemia in patients undergoing noncardiac surgery. JAMA, 1992, 268: 205-209.
  • 5Mangano DT, Layug EL, Wallace A, et al. Effect of atenolol on mortality and cardiovascular morbidity after noncardiac surgery. N Engl J Med, 1996, 335: 1713-1720.
  • 6Kersten JR, Gross GJ, Pagel PS, et al. Activation of adenosine triphosphate-regulated potassium channels:mediation of cellular and organ protection. Anesthesiology, 1998,88:495-513.
  • 7Tuman K J, Mccarthy RJ, March RJ, et al. Effects of epidural anesthesia and analgesia on coagulation and outcome alter major vascular surgery. Anesth Analg, 1991,73:696-704.
  • 8Wartier DC, Pagel PS, Kersten JR. Approaches to the prevention of perioperative myocardial ischemia. Anesthesiology, 2000,92 : 253-259.
  • 9Raby KE,Brull SJ,Timimi F,et al. The effect of heart rate control on myocardial ischemia among high-risk patients after vascular surgery. Cardiovasc Anesth, 1999,88:477-482.
  • 10McAPI-Europe Research Group. Perioperative sympatholysis: beneficial effects of the alpha 2-adrenoceptor agonist mivazerol on hemodynamic stability and myocardial ischemia. Anesthesiology, 1997,86 : 346-363.

共引文献52

同被引文献22

引证文献2

二级引证文献33

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部