IL-6基因-174C/G多态性与结核病易感性关系的Meta分析

Association of IL-6-174C /G Gene Polymorphism with Tuberculosis Risk: A Meta-Analysis

目的：探讨 IL-6基因 SNP-174 C/G 位点多态性与结核病易感性的关系。方法利用计算机检索PubMed、Medline、EMbase、CNKI、CBM、VIP和万方数据库等搜集相关病例对照研究。文献经筛选和方法学质量评价后，采用Stata12．0软件进行Meta分析，计算合并OR值及其95％CI，最后进行敏感性分析及发表偏倚评估。结果共7篇文献纳入研究，其中病例组（结核病患者）1138例，对照组（健康体检者）1311例。 Meta分析结果显示，野生型G等位基因者结核病发病率高于突变型C等位基因者（ OR＝0．77，95％CI：0．64～0．91，P＜0．05）；野生型纯合子基因型（GG）者结核病发病率高于杂合子基因型（CG）者（OR＝0．72，95％CI：0．57～0．90，P＜0．05）；在显性遗传模式中CC＋CG基因型者结核病发病率低于GG基因型者（OR＝0．71，95％CI：0．57～0．88，P＜0．05）。对纳入研究以种族为分层因素进行分析，亚洲人群G等位基因者、野生纯合子基因型（ GG）者及显性遗传模式GG基因型者结核病发病率高于C等位基因者、杂合子基因型（ CG）者及CC＋CG基因型者。经Begg′s与Egger′s检验，纳入的所有研究未见明显发表偏倚。结论 IL-6基因-174C/G多态性中的等位基因G可能与结核病易感性风险增高相关，这种情况可能只存在于亚洲人群中。

Objective To investigate the association between interleukin-6 （ IL-6 ） gene promoter SNP 174 polymor-phism and tuberculosis susceptibility .Methods Databases including PubMed , MEDLINE and EMbase data were searched to collect the published case-control studies .According to the inclusion and exclusion criteria , the studies were screened and the data were extracted .The method quality of included studies were evaluated .Then meta-analysis was conducted by using Stata 12.0 sotware.The pooled odds ratio （ORs） with 95%conidence interval （CI） were calculated and the sensi-tivity and publication bias were evaluated at the same time .Results A total of 7 studies were included , which involved 1 138 cases and 1 311 healthy controls.The results of meta-analysis showed the IL-6-174C/G polymorphism might be associ-ated with a decreased risk of TB （C vs.G：OR=0.77, 95%CI：0.64-0.91;CC vs.GG： OR=0.72, 95% CI：0.57-0.90;CC＋CG vs.GG：OR=0.71, 95%CI：0.57-0.88）.In the stratified analysis by ethnicity, significantly decreased risk of TB was associated with Asians for IL-6 -174 C/G polymorphism in C allele vs .G allele, CC vs.GG and CC＋CG vs.GG.All of the included studies showed no publication bias by Begg ＆#39;s and Egger＆#39;s test.Conclusions IL-6 -174C/G polymorphism in allele G might be a genetic risk factor which increase TB susceptibility in Asians .