摘要
目的:探讨 IL-6基因 SNP-174 C/G 位点多态性与结核病易感性的关系。方法利用计算机检索PubMed、Medline、EMbase、CNKI、CBM、VIP和万方数据库等搜集相关病例对照研究。文献经筛选和方法学质量评价后,采用Stata12.0软件进行Meta分析,计算合并OR值及其95%CI,最后进行敏感性分析及发表偏倚评估。结果共7篇文献纳入研究,其中病例组(结核病患者)1138例,对照组(健康体检者)1311例。 Meta分析结果显示,野生型G等位基因者结核病发病率高于突变型C等位基因者( OR=0.77,95%CI:0.64~0.91,P<0.05);野生型纯合子基因型(GG)者结核病发病率高于杂合子基因型(CG)者(OR=0.72,95%CI:0.57~0.90,P<0.05);在显性遗传模式中CC+CG基因型者结核病发病率低于GG基因型者(OR=0.71,95%CI:0.57~0.88,P<0.05)。对纳入研究以种族为分层因素进行分析,亚洲人群G等位基因者、野生纯合子基因型( GG)者及显性遗传模式GG基因型者结核病发病率高于C等位基因者、杂合子基因型( CG)者及CC+CG基因型者。经Begg′s与Egger′s检验,纳入的所有研究未见明显发表偏倚。结论 IL-6基因-174C/G多态性中的等位基因G可能与结核病易感性风险增高相关,这种情况可能只存在于亚洲人群中。
Objective To investigate the association between interleukin-6 ( IL-6 ) gene promoter SNP 174 polymor-phism and tuberculosis susceptibility .Methods Databases including PubMed , MEDLINE and EMbase data were searched to collect the published case-control studies .According to the inclusion and exclusion criteria , the studies were screened and the data were extracted .The method quality of included studies were evaluated .Then meta-analysis was conducted by using Stata 12.0 sotware.The pooled odds ratio (ORs) with 95%conidence interval (CI) were calculated and the sensi-tivity and publication bias were evaluated at the same time .Results A total of 7 studies were included , which involved 1 138 cases and 1 311 healthy controls.The results of meta-analysis showed the IL-6-174C/G polymorphism might be associ-ated with a decreased risk of TB (C vs.G:OR=0.77, 95%CI:0.64-0.91;CC vs.GG: OR=0.72, 95% CI:0.57-0.90;CC+CG vs.GG:OR=0.71, 95%CI:0.57-0.88).In the stratified analysis by ethnicity, significantly decreased risk of TB was associated with Asians for IL-6 -174 C/G polymorphism in C allele vs .G allele, CC vs.GG and CC+CG vs.GG.All of the included studies showed no publication bias by Begg 's and Egger's test.Conclusions IL-6 -174C/G polymorphism in allele G might be a genetic risk factor which increase TB susceptibility in Asians .
出处
《山东医药》
CAS
2014年第30期11-13,共3页
Shandong Medical Journal
基金
国家临床重点专科项目(2012ZX10004-207)