摘要
目的研究离子强度对甲氨蝶呤-树枝状大分子纳米粒稳定性的影响。方法以粒径及载药量变化为主要指标,分别考察不同离子(Na+、Cl-)及不同浓度氯化钠溶液对载药纳米粒稳定性的影响。结果确定Cl-起到稳定载药纳米粒的作用,且溶液中氯化钠质量分数<1.80%时,对纳米粒稳定作用明显。结论质量分数<1.80%的氯化钠溶液使得载药纳米粒稳定性明显增加,有助于长期储存。
Objective To investigate the influence of ionic strength on the stability of the methotrexate-loaded dendrimer nanoparticles. Methods The influences of different ions（Na^＋,Cl^-） and different concentrations of sodium chloride on the stability of the nanoparticles were studied. The particle size was measured by dynamic light scattering（ DLS） and drugloading content was determined by high-performance liquid chromatography（HPLC） in order to evaluate the stability. Results The Cl^-was finally verified to play an important role in stabilizing the nanoparticles and the effective concentration of the sodium chloride was recommended to be below 1. 80%. Conclusion The recommended concentration（ less than 1. 80%） of the sodium chloride significantly improves the stability of the nanoparticles and benefits for long term storage.
出处
《医药导报》
CAS
北大核心
2014年第10期1365-1369,共5页
Herald of Medicine
基金
国家自然科学基金资助项目(21004079)
关键词
甲氨蝶呤
离子强度
粒径
纳米粒
稳定性
Methotrexate
Ionic strength
Size
Nanoparticles
Stability
