自拟芪参通络汤对缺血性中风患者脑保护机制的研究

Research of Self-made Qishentongluo Decoction on Brain Protection Mechanism of Patients with Ischemic Stroke

目的研究自拟参芪通络汤对缺血性中风患者脑保护机制。方法将236例气虚血瘀兼水湿停滞型缺血性中风患者随机分为治疗组和对照组(治疗组116例、对照组117例)。对照组予临床基础治疗,治疗组在基础治疗的基础上给予自拟参芪通络汤口服,总疗程为14 d,检查两组治疗前及治疗后血可溶性肿瘤坏死因子相关凋亡诱导配体(sTRAI)、骨保护素(OPG)、血浆超敏C反应蛋白(hs-CRP)、血清过氧化物歧化酶(SOD)、丙二醛(MDA),治疗前及治疗后2 d、7 d、14 d血清基质金属蛋白酶-9等,并进行统计学处理。结果治疗组治疗后血sTRAI、OPG、hs-CRP、SOD、MDA改善明显高于对照组(P<0.01),治疗后2 d、7 d、14 d血MMP-9改善程度也显著优于对照组(P<0.01)。结论自拟芪参通络汤治疗缺血性中风,能够多途径、多靶点的进行脑保护。

Objective： To study self-made Qishentongluo Decoction on brain protection mechanism of patients with ischemic stroke. Methods： 236 cases of qi deficiency and blood stasis and stagnation of wet type patients with ischemic stroke were randomly divided into two groups： treatment group and control group （116 cases in ac- tual treatment group 116 cases and 117 cases in control group）. The treatment group on the basis of basic treat- ment was given Qishentongluo Decoction orally. Total treatment lasted for 14 d. Blood sTRAI, OPG, hs-CRP, SOD and MDA before and after treatment and blood MMP-9 before and after 2 d,7 d, 14 d were checked and statisti- cally processed. Results： After treatment, blood sTRAI, OPG, hs-CRP, SOD, MDA of treatment group improved significantly higher than those of control group （P〈 0.05 ,P 〈 0.01）, and blood MMP-9 improvement of treatment group was also significantly better than that of control group after treatment of 2 d and 7 d （P〈 0.05,P〈 0.01）. Conclusion： The self-made Qishentongluo Decoction can protect the brain function with many ways and many targets.