疏肝健脾固髓方加减联合常规疗法治疗多发性硬化急性期的临床研究

Clinical Study of Shuganjianpi Gusui Decoction Combined Conventional Western Medicine Treating Multiple Sclerosis in Acute Phase

目的观察疏肝健脾固髓方加减联合常规西医辨治多发性硬化急性期临床效果。方法将70例患者随机分为两组,对照组35例,予西医常规治疗,观察组35例加用疏肝健脾固髓方加减治疗,观察临床效果。结果对照组总有效率77.14%,观察组总有效率91.43%;对照组不良反应发生率31.43%,观察组总发生率为5.71%,两组差异均有统计学意义(均P<0.05)。治疗后在神经功能缺损程度评分、神经功能障碍评分和肢体疼痛无力、视力模糊、二便障碍、感觉异常、行走不稳积分方面差异均有统计学意义(均P<0.05)。结论疏肝健脾固髓方加减联合西医常规辨治多发性硬化急性期可改善临床症状,提高效果。

Objective： To investigate clinical effects of Shuganjianpi Gusui Decoction combined conventional western medicine treating multiple sclerosis in acute phase to improve clinical diagnosis and treatment. Methods： 70 cases with multiple sclerosis in acute phase were divided into two groups. 35 patients in control group were treated with conventional western medicine while 35 cases in observation group were treated with Shuganjianpi Gusui Decoction. Clinical effects were observed after treatment. Results： The total efficiency was 77.14% in the control group and 91.43% in the observation group ;the overall incidence of adverse reactions was 31.43% in the control group,and 5.71% in the observation group. The difference has statistical significance （P 〈 0.05）. After treatment, differences of neurological function, neurological dysfunction score and limb pain,weakness,blurred vi- sion, second defecation disorder, paresthesia, unsteady gait integral were statistically significant （P 〈 0.05）. Con- clusion： Shuganjianpi Gusui Decoction combined conventional western medicine treating multiple sclerosis in a- cute phase can improve clinical symptoms and effects.