人参皂苷辅助治疗肾病综合征的随机双盲对照研究

Double-blind randomized controlled clinical study on auxiliary treatment of nephrotic syndrome by Ginsenosides

目的观察人参皂苷联合糖皮质激素防治肾病综合征(NS)的临床疗效,验证人参皂苷增强糖皮质激素效应的观点。方法将120例NS患者随机分为A组和B组,在常规泼尼松治疗的基础上,A组给予人参皂苷胶囊50 mg/次,2次/d口服,B组给予安慰剂胶囊50 mg/次,2次/d口服,疗程均为12个月。观察2组治疗前后中医临床症状、肝肾功能、血脂、血浆白蛋白、24 h尿蛋白定量变化情况及激素的减量情况和临床总体疗效。结果 A组总体临床疗效明显优于B组(P<0.05);在降低24 h尿蛋白定量、减轻糖皮质激素不良反应方面效果较B组明显(P均<0.05);泼尼松减量幅度较B组明显(P<0.05)。结论人参皂苷可以增强糖皮质激素治疗NS的临床效应,减少糖皮质激素的临床用量。

Objective It is to observe the clinical effect of Ginsenosides combining with glucocorticoid on nephritic syndrome（NS）,and to verify the view point that Ginsenosides could strengthen the effect of glucocorticoid.Methods 120 patients with NS were randomly divided into group A and group B.On the basis of routine treatment with prednisone,Group A was given Ginsenosides capsule,and group B was given placebo capsule,both the drugs were given 50 mg by oral administration twice each day.Both the treatment courses were 12 months.The changes of traditional Chinese medicine symptoms,hepatorenal function,blood fats,blood plasma albumin and 24 hour urine protein quota before and after treatment,dosage decrement of prednisone and clinical effect were observed in both groups.Results The total clinical curative effect in group A was significantly better than that in group B（P〈0.05）,while the effects of decreasing 24 h hour urine protein quota and relieving side effects of glucocorticoid were better than those in group B（P〈0.05）,dosage decrement of prednisone was more than that in group B（P〈0.05）.Conclusion Ginsenosides maybe strengthen the clinical effect of glucocorticoid on NS,and decrease glucocorticoid usage.