维生素C对S_(180)移植腹水瘤荷瘤小鼠的影响

Study on Effects of Vitamin C on Mice Transplanted S_(180) Fluid Tumor

目的 研究不同剂量维生素C对S180 移植腹水瘤荷瘤小鼠一般状况及免疫水平的影响。方法 建立小鼠S180 移植腹水瘤模型 ,维生素C干预 7天后处死 ,测定小鼠血红蛋白含量 ,白细胞数目及体液免疫指标 (血清溶血素 )。细胞免疫指标 (小鼠足跖肿胀实验 )和脏 /体重比值。结果 维生素C对荷瘤小鼠的血象改变有一定保护作用 ,对免疫脏器损伤有一定保护 ,但总体未见显著性差异 (P >0 0 5 ) ;维生素C对荷瘤小鼠的免疫功能具有显著保护作用 (P<0 0 1,P <0 0 5 ) ,且呈剂量依赖趋势。结论 维生素C可提高荷瘤小鼠的免疫功能 。

Objective To study the effect of different dosages of vitamin C on the general condition and immunity level of mice transplanted S 180 fluid tumor.Methods The model for transplanted S 180 fluid tumor in mice was set up.The mice were given vitamin C for 7 days and then were killed.The amount of hemoglobin(Hb),the number of white blood cell(WBC),the index of humoral and cellular immunity,the ratio of weight of internal organs to that of mice body were determined.Results Vitamin C had the protective effect on the change of hemogram in tumor-bearing mice and on the damage of immunological organs.But there was not statistical difference.Vitamin C had the evidently protective effect on the immunological function of tumor-bearing mice by using statistical analysis and the degree of this effect depended on dosage.Conclusion Vitamin C can increase the immunological function of tumor-bearing mice,decrease the damage of internal organs in tumor-bearing mice,and can improve the amount of Hb.