中性粒细胞明胶酶相关载脂蛋白检测对子痫前期的诊断意义

Value of Neutrophil Gelatinase-associated Lipocalin in the Diagnosis of Preeclampsia

【目的】探讨中性粒细胞明胶酶相关载脂蛋白（NAGL）检测对子痫前期的诊断意义。【方法】随机将本院门诊2010年1月至2012年11月定期进行产前检查的产妇纳入研究，其中50例孕前诊断为子痫前期（观察组），选择30例同期健康单胎产妇作为对照组。收集两组临床资料，并采用 ELISA 法检测血和尿NGAL值并进行比较。【结果】观察组与正常对照组孕龄、孕前体质量指数（BMI）值相比较差异无显著性（ P＞0．05）；胎儿出生体质量、收缩压和舒张压以及血和尿 NAGL 两组间相比较差异具有统计学意义（P＜0．01）。血NGAL对子痫前期诊断敏感性为78％（39/50），特异性为90％（27/30），经Kappa检验评估显示 k值为0．65，一致性好。【结论】 NAGL在子痫前期患者中表达增高，可能作为预测子痫前期的指标。

[Objective]To explore the value of neutrophil gelatinase-associated lipocalin（NGAL） in the diagnosis of preeclampsia（PE） .[Methods] The parturients who received prenatal examination in the outpatient department of our hospital from Jan .2010 to Nov .2012 were randomly enrolled in the study .Among them , 50 cases were diagnosed as PE（observation group） .Other 30 healthy single-birth parturients were selected as control group in the same period .Clinical data of two groups were collected .ELISA was used to detect and compare NGAL value in blood and urine .[Results] There was no significant difference in maternal age and progestation body mass index （BMI） between observation group and normal control group （ P 〉0 .05） .There were significant differences in fetal birth weight ,systolic pressure ,diastolic pressure and NAGL in blood and urine between two groups（ P 〈0 .01） .The sensitivity and specificity of blood NGAL in the diagnosis of PE were 78% （39/50） and 90% （27/30） ,respectively .Kappa test showed that k value was 0 .65 with good consistency .[Conclusion] The expression of NGAL in patients with PE is increased and may be used as a marker for predicting PE .