盐酸氟西汀联合逍遥丸治疗孕中期引产产妇产后抑郁的疗效

Efficacy of Fluoxetine Hydrochloride Combined with Xiaoyao Pill for the Treatment of Postpartum Depression in Puerperas after Induction of Labor in Second Trimester

【目的】探讨盐酸氟西汀联合逍遥丸治疗孕中期引产产妇产后抑郁的疗效。【方法】52例孕中期引产产后抑郁症产妇，随机分为对照组和观察组，每组26例，对照组产妇仅服用盐酸氟西汀，观察组产妇服用盐酸氟西汀和逍遥丸，均治疗4周，参照汉密尔顿抑郁量表（HDM A）和副作用量表（T ESS）评定两种治疗方法的疗效和副作用。【结果】观察组总有效率为96．15％，高于对照组（92．31％），但差异无统计学意义（P＞0．05），观察组患者痊愈率显著高于对照组（P＜0．05）；两组治疗后随着治疗时间的延长，HDMA 减分率均明显递增（P＜0．05）；治疗后第1周、第2周观察组TESS得分（6．87±2．38，6．06±2．71）明显小于对照组（9．12±3．03，8．01±2．97）（P＜0．05）。【结论】逍遥丸的配合治疗在一定程度上可提高盐酸氟西汀治疗产后抑郁疗效而减弱其副作用。

[Objective]To explore the efficacy of fluoxetine hydrochloride combined with Xiaoyao pill for the treatment of postpartum depression in puerperas after induction of labor in second trimester .[Methods]A total of 52 puerperas with postpartum depression after induction of labor in second trimester were randomly divided into control group and observation group with 26 cases in each group .The control group was only treated with fluoxetine hydrochloride ,while the observation group was treated with fluoxetine hydrochloride and Xiaoyao pill .The treatment in two groups lasted four weeks .The efficacy and adverse reaction of two treatment methods were assessed by Hamilton depression scale（HDMA） and adverse reaction scale（TESS） .[Results]The total effective rate of the observation group was 96 .15% ,which was higher than that（92 .31% ） of the control group（ P〉0 .05） ,but the full recovery rate of the observation group was significantly higher than that of the control group （ P〈0 .05） . With the prolongation of treatment time ,the deducted rate of HDMA in two groups was increased gradually （ P〈0 .05） .The TESS score in observation group at 1st and 2nd week after treatment was obviously less than that in control group[（6 .87 ± 2 .38 ,6 .06 ± 2 .71） vs .（9 .12 ± 3 .03 ,8 .01 ± 2 .97）]（ P 〈0 .05） .[Conclusion] The partner treatment of Xiaoyao pill can increase the efficacy of fluoxetine hydrochloride for the treatment of postpartum depression and decrease the adverse reaction in a certain degree .