地佐辛和吗啡用于胆囊切除术后静脉镇痛的比较

Comparison of intravenous dezocine and morphine in postoperative patient of cholecystectomy

目的比较地佐辛和吗啡用于胆囊切除术后静脉自控镇痛（PCIA）的效果及安全性。方法 80例ASAⅠ~Ⅱ级择期在全麻下行胆囊切除术的患者随机分为地佐辛组和吗啡组,进行静脉自控镇痛（PCIA）,每组40例。地佐辛组用地佐辛40mg,吗啡组用吗啡40mg,分别以生理盐水加昂丹司琼3mg稀释至100mL,以LCP模式给药。观察术后4、8、16、24h的镇痛评分（VAS）、镇静评分（Ramsay）及不良反应发生情况。结果 2组患者术后各时间点VAS及Ramsay评分差异无显著性（P〉0.05）,组间比较差异有显著性（P〈0.01）。地佐辛组出现恶心、呕吐2例,吗啡组出现恶心、呕吐11例,皮肤瘙痒12例。结论地佐辛可安全地用于胆囊切除术后静脉自控镇痛,其镇痛效果与吗啡相当,不良反应发生率明显低于吗啡。

Objective To compare the analgesia efficacy and safety of dezocine and morphine in patient-controlled intravenous analgesia in postoperative patient of cholecystectomy.Methods 80 cases of ASAⅠ-levelⅡ elective patients with cholecystectomy under general anesthesia were randomly divided into with sheen and morphine group,for self-control analgesia（PCIA）,40 cases in each group.To assist symplectic group land with 40 mg,40mg with morphine,morphine group respectively with physiological saline,Dan SiQiong 3mg diluted to 100 mL,the LCP model.To observe the postoperative 4h,8h,16 h,24hof VAS pain score,Ramsay sedation scores,and adverse reactions occur.Results VAS,Ramsay scale and satisfaction scale showed no significant difference between the two groups.The dosage of analgesic consumption within 24 hours was significantly higher in group D than that in group M（P〈0.01）.The incidence of adverse events was significantly lower in group D than that in group M（P〈0.01）.Conclusion Dezocine call be safely administrated to postoperative patient of cholecystectomy undergoing orthopedic surgery via PCIA with equal analgesic efficacy as morphine but fewer adverse reactions.