摘要
目的探讨云南哈尼族人群与人类免疫缺陷病毒(HIV)感染相关的SDF1-3'A、CCR2-64I、CX3CR1基因多态性分布。方法通过MassARRAY检测技术分析了78例云南哈尼族人群SDF1-3'A、CCR2-64I、CX3CR1单核苷酸多态性,通过与国内外研究结果比较,探讨其特点。结果在SDF1-3'A位点上明显高于美国黑人;在CCR2-64I位点上明显高于汉族、黎族、仫佬族、美国黑人和高加索人;在CX3CR1-V249I和CX3CR1-T280M位点,均明显低于高加索人。结论云南哈尼族人群可能对HIV感染具有较强的抵抗力,能延缓艾滋病的发病进程。
Objective： To study the gene-polymorphism of HIV resistant SDF1- 31A, CCR2-64I, CX3CR1 alleles in Yunnan Hani populations. Methods： The polymorphisms of SDF1- 31A, CCR2-64I and CX3CR1 alleles were analyzed through MassARRAY and compared with other studies. Result： It was higher than American black in SDF1-31A; It was higher than Han, Li, Mulao, Caucasian and American black in CCR2-64I; It was lower than Caucasian in CX3CR1. Conclusion： The I-Iini population of Yunnan would have stronger protection against infection of HIV and was not easy to develop into AIDS.
出处
《中国优生与遗传杂志》
2014年第9期42-43,6,共3页
Chinese Journal of Birth Health & Heredity
基金
云南省科技厅面上资助项目(2008ZC150M)
