体外受精-胚胎移植妊娠早期流产相关因素分析

Related factors of early abortion among pregnancies conceived by in vitro fertilization-embryo transfer

目的探讨体外受精-胚胎移植(IVF-ET/ICSI)妊娠后发生早期流产的可能相关因素。方法将IVF或ICSI获得妊娠的735个周期,按妊娠结局分为早期流产组和继续妊娠组,分析IVF/ICSI妊娠后发生早期流产的可能相关因素。结果早期流产组患者年龄和胚胎移植数明显高于继续妊娠组(P<0.01);窦卵泡数、hCG日E2、P值、获卵数均明显低于继续妊娠组(P<0.01)。Logistic回归分析显示年龄增高及获卵数减少是发生早期自然流产的危险因素。结论 IVF/ICSI治疗周期中患者年龄、窦卵泡数、hCG日E2、P值、获卵数、移植胚胎数与早期流产相关,年龄增高及获卵数减少可增加早期自然流产风险。

Objective： To explore the potential related factors of early abortion in in vitro fertilization-embryo transfer. Methods： A total of 735 gestational cycles of IVF / ICSI were divided into two groups, early pregnancy loss group （group A） and ongoing pregnancy group （group B ） . The potential related factors of early abortion were evaluated. Results： The average age of the women and the number of transferred embryo in the group A was more than that of the group B （P〈 0.01 ） ; Antral follicle count, estrogen and progesterone in the day of human chorionic gonadotrophin （hCG） injection, the number of retrieved oocytes in the study group A were lower than those of the group B （P〈0.01） . Logistic regression analys is showed that the advanced age and decreased number of retrieved oocytes were risk factors of early abortion. Conclusion： Age of the patient, antral follicle count, estrogen and progesterone in the day of HCG injection, the number of retrieved oocytes, number of transferred embryo were related to the occurrence of early abortion in IVF / ICSI treatment cycles. The advanced age and decreased number of retrieved oocytes can increase the risk of early abortion.