摘要
目的：研究磺丁基醚-β-环糊精对伏立康唑的增溶作用及不同pH下伏立康唑的稳定性。方法：采用相溶解度法考察不同pH下磺丁基醚-β-环糊精对伏立康唑的增溶作用,同时考察伏立康唑有关物的变化情况。结果：伏立康唑在磺丁基醚-β-环糊精溶液中溶解度明显提高,在pH5.0~8.0范围内包合物的表观稳定常数相近（Kc）;随pH增加伏立康唑稳定性下降。结论：磺丁基醚-β-环糊精是伏立康唑的理想增溶剂,pH会影响伏立康唑的稳定性。
Objective： To research the solubilization of sulfobutyl ether-β-cyclodextrin（ SEB-β-CD） on voriconazole and the stability of voriconazole with different pH values. Methods： Phase-solubility diagram was applied to study the solubilization of SEB-β-CD on voriconazole. Meanwhile,the impurity of voriconazole was determined to study the stability. Results： SBE-β-CD could increase the solubility of voriconazole significantly and the apparent stability constant was similar within the pH range of 5. 0-8. 0. The stability of voriconazole was decreased with the increase of pH. Conclusion： SEB-β-CD is an ideal solubilizer for voriconazole,while the stability is influenced by pH.
出处
《中国药师》
CAS
2014年第9期1457-1460,共4页
China Pharmacist
基金
科技部"十一五"重大新药创制项目(编号:2011ZX09401-306)
