健脾消胀片对大鼠胆汁分泌的影响

Effect of Jianpi Xiaozhang Tablets on Biliation in Rats

目的:观察健脾消胀片对大鼠胆汁分泌的影响。方法:大鼠60只,分为6组,分别灌服健脾消胀片(大、中、小剂量)混悬液;舒胆通混悬液;清肝利胆胶囊混悬液和同体积的0.5%羧甲基纤维素;每天给药1次,连续给药5 d。收集各组大鼠胆汁量,检测胆汁中总胆汁酸、总胆固醇、总胆红素等含量。结果:健脾消胀片可使大鼠胆汁中胆汁酸、胆红素含量显著升高(P<0.01),胆固醇含量显著降低(P<0.01)。结论:健脾消胀片有促进胆汁分泌的作用。

Objective： To observe the effect of Jianpi Xiaozhang tablets on the bile secretion in rats. Methods： Totally 60 rats were divided into 6 groups randomly. Jianpi Xiaozhang tablet suspension （ high, moderate, tow dosages）, Shudantong suspension, Qinggan Lidan capsule suspension and 0.5% carboxymethyl cellulose with the same volume was respectively given with intragastric gavage once daily for continuous 5 days. The bile was collected to detect total bile acids （TBA） , total cholesterol and total bilirubin. Re- suits： Jianpi Xiaozhang tablets could notably increase TBA and total bilirubin in the bile （P 〈 0.01 ）, and decrease the cholesterol content significantly （P 〈 0.01 ）. Conclusion ： Jianpi Xiaozhang tablets can promote the bile secretion.