蕲蛇对益气养阴祛瘀方治疗干燥综合征临床疗效的干预作用

The Intervention Effect of Agkistrodon in Treating Sjogren's Syndrome with YiQiYangYinQuYu Medicine

[目的]观察中药蕲蛇对干燥综合征(Sjogren's syndrome,SS)患者的临床疗效并初步探索其作用机理。[方法]对52例患者随机分成两组:治疗组26例,服用益气养阴祛瘀方+蕲蛇;对照组26例,服用益气养阴祛瘀方。观察各组患者研究前后临床症状、疾病活动度、中医证候、生存质量、实验室指标等变化情况。[结果]治疗组与对照组相比,临床症状好转,疾病活动度评分、生存质量评分、免疫功能均有所改善,尤其是免疫球蛋白G(IgG)有大幅度下降。[结论]蕲蛇水煎剂能减轻干燥综合征患者病情,改善生活质量,这可能与其免疫抑制功能有关。

[Objective] To observe the chnical efficacy of Agkistrodon in treating Sjogren＇s syndrome. [Methods] 52 patients were randomly divided into two groups： Treatment of 26 patients taking Agkistrodon and the basic prescription medicine（YIQIYANGYINQUYU drugs）; 26 patients in the control received the basic prescription medicine. The chnical symptoms,the disease activity score of SSDAI,the score of TCM symptom and life quality and the index of serology were recorded in this clinical observation. [Results] The treatment group had better results of immune function than the control group after treatment, in particular had a substantial decrease in IgG. In addition, the chnical symptoms, the disease activity score of SSDAI, the score of TCM symptom and hfe quality were improved. [Conclusion] Agkistrodon has significantly immunosuppressive effects on the patients with Sjogren＇s syndrome, thus improving the patients＂ condition, the standard of hving and the quality of life.