益骨口服液对去势大鼠骨质疏松症痛阈及骨密度的影响

Influence of YIGU Oral Liquid on Ovariectomized Rats with Pain Threshold and Bone Density

[目的]观察益骨口服液对去势大鼠骨质疏松症痛阈及骨密度的影响。[方法]将84只SD大鼠随机分益骨口服液组、密盖息组、益骨口服液及密盖息联合组、生理盐水对照组,每组各21只;造模成功后,分别予益骨口服液、密盖息、益骨口服液及密盖息、生理盐水等不同药物灌胃,于治疗后第10d、第30d、第60d、第90d四个时点分别测量各组大鼠痛阈、股骨骨密度。[结果]治疗第10d、30d、60d、90d益骨口服液组、密盖息组、益骨口服液及密盖息联合组与对照组相比,去势大鼠痛阈明显升高,差异有统计学意义(P<0.05)。治疗第10d、30d,益骨口服液组、密盖息组、益骨口服液及密盖息联合组股骨骨密度与对照组相比,差异无统计学意义(P>0.05),在治疗第60d、90d时,骨密度明显提高差异有统计学意义(P<0.05)。[结论]益骨口服液能提高去势大鼠痛阈、骨密度,从而减轻骨质疏松大鼠疼痛。

[Objective] To observe the influence of YIGU oral liquid on the pain threshold and bone mineral density in ovariectomJzed rats. [Methods] Eighty-four Female SD rats were randomly divided into 4groups：YIGU oral liquid group, calcitonin group,YIGU oral liquid combined with calcitonin group, saline control group.The ovariectomized rats were confirmed the successful model of osteoporosis,rats in the YIGU oral liquid group were administered with YIGU oral liquid, rats in the calcitonin group were administered with calcitonin, rats in the YIGU oral liquid combined with calcitonin group were administered with YIGU oral liquid group and calcitonin,rats in the saline control group were administered with saline.To detect the pain threshold and bone mineral density at the 10th day, 30th day, 60th day and 90th day respectively. [Results]At the 10th, 30th, 60th and .90th day after treatment, the pain threshold of the YIGU oral liquid group, calcitonin group,YIGU oral liquid combined with calcitonin group compare to saline control group, there was significant statistical difference（P〈0.05）.At the 10th, 30th day after treatment,the bone mineral density of the YIGU oral liquid group, calcitonin group,YIGU oral liquid combined with calcitonin group compared with saline control group, there was no significant statistical difference（P〉O.05）. At the 60th,90th day after treatment, there was significant statistical difference（P〈0.05）. [Conclusion] YIGU oral liquid can effectively enhance pain thresh- old and bone mineral density of the ovariectomized rats to inhibit the osteoporosis pain.